A0A0G2K3B1 · A0A0G2K3B1_RAT

  • Protein
    Cystic fibrosis transmembrane conductance regulator
  • Gene
    Cftr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell surface
Cellular Componentchloride channel complex
Cellular Componentcytosol
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentrecycling endosome membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionbicarbonate transmembrane transporter activity
Molecular Functionchloride channel inhibitor activity
Molecular Functionenzyme binding
Molecular Functionintracellularly ATP-gated chloride channel activity
Molecular Functionisomerase activity
Molecular FunctionPDZ domain binding
Molecular Functionprotein-folding chaperone binding
Molecular FunctionSec61 translocon complex binding
Biological Processamelogenesis
Biological Processcellular response to cAMP
Biological Processcellular response to forskolin
Biological Processcholesterol biosynthetic process
Biological Processcholesterol transport
Biological Processestablishment of localization in cell
Biological Processintracellular pH elevation
Biological Processmembrane hyperpolarization
Biological Processmulticellular organismal-level water homeostasis
Biological Processpositive regulation of enamel mineralization
Biological Processpositive regulation of exocytosis
Biological Processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Processresponse to endoplasmic reticulum stress
Biological Processsperm capacitation
Biological Processtransepithelial water transport
Biological Processvesicle docking involved in exocytosis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cystic fibrosis transmembrane conductance regulator
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 7
    • Channel conductance-controlling ATPase
    • cAMP-dependent chloride channel

Gene names

    • Name
      Cftr

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A0G2K3B1

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane308-332Helical
Transmembrane384-404Helical
Transmembrane410-430Helical
Transmembrane493-514Helical
Transmembrane1043-1068Helical
Transmembrane1170-1192Helical
Transmembrane1198-1217Helical
Transmembrane1289-1307Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-112Disordered
Domain271-512ABC transmembrane type-1
Domain601-835ABC transporter
Domain1044-1342ABC transmembrane type-1
Domain1397-1628ABC transporter
Region1634-1665Disordered
Compositional bias1648-1665Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,665
  • Mass (Da)
    188,768
  • Last updated
    2015-07-22 v1
  • Checksum
    2599CDAB38F4C5B6
MDLEKLTGGGGGRKEEEREEKGEQSEGKDSVGEGREREEGGEREEGGEREEGRGAVGREEGGRGQRDQGGQREGERERDREKSEGGERGGEGKEEKEGEEREGQGEGRERFREAKGISDWSLFLSKKDSKSRRLAMVYPGPLSEPLLGPPCEGLSKREEPKALNGSWISRSRVQPEPVRTQTLVHHGDIMQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDREQASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSSEKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P34158CFTR_RATCftr1476
A0A8I6AKE9A0A8I6AKE9_RATCftr1662
A0A8I6AKF6A0A8I6AKF6_RATCftr1446
A0A8I6AU15A0A8I6AU15_RATCftr530
A0A8I6A376A0A8I6A376_RATCftr1499

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1648-1665Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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