A0A0G2JZ43 · A0A0G2JZ43_RAT
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePlcb2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1183 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | neuronal dense core vesicle | |
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol metabolic process | |
Biological Process | sensory perception of bitter taste |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A0G2JZ43
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 440-533 | Disordered | ||||
Sequence: FPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKM | ||||||
Compositional bias | 503-525 | Acidic residues | ||||
Sequence: TEVEEGEEEEEVEEEEEEESGNL | ||||||
Domain | 550-666 | PI-PLC Y-box | ||||
Sequence: MSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMR | ||||||
Domain | 666-794 | C2 | ||||
Sequence: RRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPL | ||||||
Region | 859-888 | Disordered | ||||
Sequence: NGAPVSAGNGSTAPGTKAKEEATKEVAEPQ | ||||||
Coiled coil | 1078-1142 | |||||
Sequence: IQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRA | ||||||
Region | 1154-1183 | Disordered | ||||
Sequence: EKPERPCEASEESCPQEPLVNKTDTQESRL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,183
- Mass (Da)134,809
- Last updated2015-07-22 v1
- ChecksumB8C0CD5CFA698971
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O89040 | PLCB2_RAT | Plcb2 | 1183 | ||
A0A8I6GEV3 | A0A8I6GEV3_RAT | Plcb2 | 1160 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 503-525 | Acidic residues | ||||
Sequence: TEVEEGEEEEEVEEEEEEESGNL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR07053499 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |