A0A0G2JZ43 · A0A0G2JZ43_RAT

  • Protein
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • Gene
    Plcb2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site327
Binding site328Ca2+ (UniProtKB | ChEBI)
Binding site357Ca2+ (UniProtKB | ChEBI)
Binding site359Ca2+ (UniProtKB | ChEBI)
Active site374
Binding site408Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentneuronal dense core vesicle
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process
Biological Processphosphatidylinositol metabolic process
Biological Processsensory perception of bitter taste

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      Plcb2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A0G2JZ43

Proteomes

Organism-specific databases

Subcellular Location

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region440-533Disordered
Compositional bias503-525Acidic residues
Domain550-666PI-PLC Y-box
Domain666-794C2
Region859-888Disordered
Coiled coil1078-1142
Region1154-1183Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,183
  • Mass (Da)
    134,809
  • Last updated
    2015-07-22 v1
  • Checksum
    B8C0CD5CFA698971
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKXMXLAIEKQAAEKNIYPLSVRSDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O89040PLCB2_RATPlcb21183
A0A8I6GEV3A0A8I6GEV3_RATPlcb21160

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias503-525Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR07053499
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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