A0A0G2JXU8 · A0A0G2JXU8_RAT

  • Protein
    Angiotensin-converting enzyme
  • Gene
    Ace2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.
chloride (UniProtKB | Rhea| CHEBI:17996 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site314Proton acceptor 1
Active site314Proton acceptor 2
Active site444Proton donor 1
Active site444Proton donor 2

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border membrane
Cellular Componentcell surface
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentextracellular space
Molecular Functioncarboxypeptidase activity
Molecular Functionendopeptidase activity
Molecular Functionidentical protein binding
Molecular Functionmetal ion binding
Molecular Functionmetallopeptidase activity
Molecular Functionpeptidyl-dipeptidase activity
Molecular Functionvirus receptor activity
Biological Processangiotensin-mediated drinking behavior
Biological Processentry receptor-mediated virion attachment to host cell
Biological Processnegative regulation of signaling receptor activity
Biological Processpositive regulation of cardiac muscle contraction
Biological Processpositive regulation of gap junction assembly
Biological Processpositive regulation of L-proline import across plasma membrane
Biological Processproteolysis
Biological Processregulation of cardiac conduction
Biological Processregulation of transmembrane transporter activity
Biological Processtryptophan transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Angiotensin-converting enzyme
  • EC number

Gene names

    • Name
      Ace2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A0G2JXU8

Proteomes

Organism-specific databases

Subcellular Location

Apical cell membrane
Cell membrane
; Single-pass type I membrane protein
Cell projection, cilium
Cytoplasm
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane680-704Helical

Keywords

PTM/Processing

Features

Showing features for glycosylation, disulfide bond.

Type
IDPosition(s)Description
Glycosylation29N-linked (GlcNAc...) (complex) asparagine
Disulfide bond72↔80
Disulfide bond283↔300
Disulfide bond469↔481
Glycosylation517N-linked (GlcNAc...) asparagine; partial

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain553-744Collectrin-like
Region710-744Disordered
Compositional bias729-744Polar residues

Sequence similarities

Belongs to the peptidase M2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    744
  • Mass (Da)
    85,661
  • Last updated
    2015-07-22 v1
  • Checksum
    2FBDF7DD1A6BCED3
MNEAAAKWSAFYEEQSKIAQNFSLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIYSTGKVCNSMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFWTNSMLTEPGDDRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIRYYTRTIYQFQFQEALCQAAKHDGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSPYADQSIKVRISLKSALGKNAYEWTDNEMYLFRSSVAYAMREYFSREKNQTVPFGEADVWVSDLKPRVSFNFFVTSPKNVSDIIPRSEVEEAIRMSRGRINDIFGLNDNSLEFLGIYPTLKPPYEPPVTIWLIIFGVVMGTVVVGIVILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNSDDAQTSF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q5EGZ1ACE2_RATAce2805

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias729-744Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR07037830
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07037831
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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