A0A0G2JXU8 · A0A0G2JXU8_RAT
- ProteinAngiotensin-converting enzyme
- GeneAce2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids744 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- angiotensin I + H2O = angiotensin-(1-9) + L-leucineThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 314 | Proton acceptor 1 | |||
Active site | 314 | Proton acceptor 2 | |||
Active site | 444 | Proton donor 1 | |||
Active site | 444 | Proton donor 2 | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A0G2JXU8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 680-704 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Glycosylation | 29 | N-linked (GlcNAc...) (complex) asparagine | |||
Disulfide bond | 72↔80 | ||||
Disulfide bond | 283↔300 | ||||
Disulfide bond | 469↔481 | ||||
Glycosylation | 517 | N-linked (GlcNAc...) asparagine; partial | |||
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 553-744 | Collectrin-like | |||
Region | 710-744 | Disordered | |||
Compositional bias | 729-744 | Polar residues | |||
Sequence similarities
Belongs to the peptidase M2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length744
- Mass (Da)85,661
- Last updated2015-07-22 v1
- Checksum2FBDF7DD1A6BCED3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5EGZ1 | ACE2_RAT | Ace2 | 805 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 729-744 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR07037830 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07037831 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |