A0A0G2JU12 · A0A0G2JU12_RAT
- ProteinMicrosomal glutathione S-transferase 2
- GeneMgst2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids119 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.
Catalytic activity
- (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | membrane | |
Cellular Component | nuclear envelope | |
Cellular Component | plasma membrane | |
Molecular Function | enzyme activator activity | |
Molecular Function | glutathione binding | |
Molecular Function | glutathione peroxidase activity | |
Molecular Function | glutathione transferase activity | |
Molecular Function | identical protein binding | |
Molecular Function | leukotriene-C4 synthase activity | |
Biological Process | glutathione biosynthetic process | |
Biological Process | leukotriene biosynthetic process | |
Biological Process | lipid metabolic process | |
Biological Process | membrane lipid catabolic process | |
Biological Process | response to lipopolysaccharide |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMicrosomal glutathione S-transferase 2
- EC number
- Short namesMicrosomal GST-2 ; Microsomal GST-II
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A0G2JU12
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Microsome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length119
- Mass (Da)13,408
- Last updated2022-05-25 v2
- ChecksumBCF22317314A0203
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5ZLK2 | A0A8I5ZLK2_RAT | Mgst2 | 147 | ||
A0A8I6ADF7 | A0A8I6ADF7_RAT | Mgst2 | 77 | ||
A0A8I5ZSH5 | A0A8I5ZSH5_RAT | Mgst2 | 82 |
Keywords
- Technical term