A0A0G2JU12 · A0A0G2JU12_RAT

  • Protein
    Microsomal glutathione S-transferase 2
  • Gene
    Mgst2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentmembrane
Cellular Componentnuclear envelope
Cellular Componentplasma membrane
Molecular Functionenzyme activator activity
Molecular Functionglutathione binding
Molecular Functionglutathione peroxidase activity
Molecular Functionglutathione transferase activity
Molecular Functionidentical protein binding
Molecular Functionleukotriene-C4 synthase activity
Biological Processglutathione biosynthetic process
Biological Processleukotriene biosynthetic process
Biological Processlipid metabolic process
Biological Processmembrane lipid catabolic process
Biological Processresponse to lipopolysaccharide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Microsomal glutathione S-transferase 2
  • EC number
  • Short names
    Microsomal GST-2
    ; Microsomal GST-II
  • Alternative names
    • Glutathione peroxidase MGST2
    • Leukotriene C4 synthase MGST2
    • Microsomal glutathione S-transferase II

Gene names

    • Name
      Mgst2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A0G2JU12

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Microsome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Keywords

PTM/Processing

Expression

Gene expression databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the MAPEG family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    119
  • Mass (Da)
    13,408
  • Last updated
    2022-05-25 v2
  • Checksum
    BCF22317314A0203
MAGDSSLLAAVSLLSACQQSYFALQVGRVRLKYKIAPPAVTGSLEFERIFRAQQNSLEFYSVFIISLWMAGWYFNQEFPMMDLNEADCLEEKVLGFCNLSGSPVHIRPSQVFLGLCRSR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5ZLK2A0A8I5ZLK2_RATMgst2147
A0A8I6ADF7A0A8I6ADF7_RATMgst277
A0A8I5ZSH5A0A8I5ZSH5_RATMgst282

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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