A0A0G2JSI1 · A0A0G2JSI1_RAT
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- GeneAldh9a1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids521 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + H2O + NAD+ = (5-hydroxyindol-3-yl)acetate + 2 H+ + NADH
- 3,4-dihydroxyphenylacetaldehyde + H2O + NAD+ = 3,4-dihydroxyphenylacetate + 2 H+ + NADH
- H2O + NAD+ + pentanal = 2 H+ + NADH + pentanoate
- H2O + NAD+ + propanal = 2 H+ + NADH + propanoate
- H2O + NAD+ + spermine monoaldehyde = 2 H+ + N-(2-carboxyethyl)spermidine + NADH
- H2O + hexanal + NAD+ = 2 H+ + hexanoate + NADH
- H2O + imidazole-4-acetaldehyde + NAD+ = 2 H+ + imidazole-4-acetate + NADH
- acrolein + H2O + NAD+ = acrylate + 2 H+ + NADH
- butanal + H2O + NAD+ = butanoate + 2 H+ + NADH
Pathway
Amine and polyamine biosynthesis; carnitine biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 278 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4-trimethylammoniobutyraldehyde dehydrogenase activity | |
Biological Process | carnitine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A0G2JSI1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-507 | Aldehyde dehydrogenase | ||||
Sequence: TEKAFEPATGREIATFKCSGEKEVNLAVENAKAAFKIWSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSIFEARLDVDTSWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLLAEIYTKAGAPNGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAAKGIKPITLELGGKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDPLLEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDDMTCVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTV |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length521
- Mass (Da)56,469
- Last updated2022-05-25 v2
- Checksum99604CF61A35AA12
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9JLJ3 | AL9A1_RAT | Aldh9a1 | 494 | ||
A0A8I6AQJ5 | A0A8I6AQJ5_RAT | Aldh9a1 | 497 | ||
A0A8I6ASL3 | A0A8I6ASL3_RAT | Aldh9a1 | 517 |
Keywords
- Technical term