Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Role of pericytes in the development of cerebral cavernous malformations.Dai Z., Li J., Li Y., Wang R., Yan H., Xiong Z., Wu S., Yang X., Lu D.[...], Shi C.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCiScience 25:105642-105642 (2022)Mapped to5
beta1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations.McCurdy S., Lin J., Shenkar R., Moore T., Lightle R., Faurobert E., Lopez-Ramirez M.A., Awad I., Ginsberg M.H.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCFASEB J 36:e22629-e22629 (2022)Mapped to5
Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease.Romanos S.G., Srinath A., Li Y., Xie B., Chen C., Li Y., Moore T., Bi D., Sone J.Y.[...], Awad I.A.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCTransl Stroke Res 14:513-529 (2023)Mapped to9
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.Hong C.C., Tang A.T., Detter M.R., Choi J.P., Wang R., Yang X., Guerrero A.A., Wittig C.F., Hobson N.[...], Kahn M.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCJ Exp Med 217:e20200140-e20200140 (2020)Mapped to60
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.Tang A.T., Sullivan K.R., Hong C.C., Goddard L.M., Mahadevan A., Ren A., Pardo H., Peiper A., Griffin E.[...], Kahn M.L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCSci Transl Med 11:eaaw3521-eaaw3521 (2019)Mapped to32
KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction.Vieceli Dalla Sega F., Mastrocola R., Aquila G., Fortini F., Fornelli C., Zotta A., Cento A.S., Perrelli A., Boda E.[...], Retta S.F.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCInt J Mol Sci 20:E4930-E4930 (2019)Mapped to5
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.Lopez-Ramirez M.A., Pham A., Girard R., Wyseure T., Hale P., Yamashita A., Koskimaki J., Polster S., Saadat L.[...], Ginsberg M.H.View abstractCategoriesFunction, ExpressionSourceMGI: 1930618PubMedEurope PMCBlood 133:193-204 (2019)Mapped to11
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.Lopez-Ramirez M.A., Fonseca G., Zeineddine H.A., Girard R., Moore T., Pham A., Cao Y., Shenkar R., de Kreuk B.J.[...], Ginsberg M.H.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCJ Exp Med 214:3331-3346 (2017)Mapped to11
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Goitre L., DiStefano P.V., Moglia A., Nobiletti N., Baldini E., Trabalzini L., Keubel J., Trapani E., Shuvaev V.V.[...], Glading A.J.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCSci Rep 7:8296-8296 (2017)Mapped to5
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.Tang A.T., Choi J.P., Kotzin J.J., Yang Y., Hong C.C., Hobson N., Girard R., Zeineddine H.A., Lightle R.[...], Kahn M.L.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCNature 545:305-310 (2017)Mapped to23
Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice.Choi J.P., Foley M., Zhou Z., Wong W.Y., Gokoolparsadh N., Arthur J.S., Li D.Y., Zheng X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCPLoS One 11:e0160833-e0160833 (2016)Mapped to14
Phosphoinositide 3-Kinase (PI3K) Subunit p110delta Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse.Hu X., Li J., Zhang Q., Zheng L., Wang G., Zhang X., Zhang J., Gu Q., Ye Y.[...], Wang L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCSci Rep 6:28201-28201 (2016)Mapped to99+
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.Cuttano R., Rudini N., Bravi L., Corada M., Giampietro C., Papa E., Morini M.F., Maddaluno L., Baeyens N.[...], Dejana E.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCEMBO Mol Med 8:6-24 (2016)Mapped to18
Endothelial Erg expression is required for embryogenesis and vascular integrity.Han R., Pacifici M., Iwamoto M., Trojanowska M.View abstractCategoriesFunction, ExpressionSourceMGI: 1930618PubMedEurope PMCOrganogenesis 11:75-86 (2015)Mapped to29
The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.Zhou Z., Rawnsley D.R., Goddard L.M., Pan W., Cao X.J., Jakus Z., Zheng H., Yang J., Arthur J.S.[...], Kahn M.L.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCDev Cell 32:168-180 (2015)Mapped to30
Lack of CCM1 induces hypersprouting and impairs response to flow.Mleynek T.M., Chan A.C., Redd M., Gibson C.C., Davis C.T., Shi D.S., Chen T., Carter K.L., Ling J.[...], Li D.Y.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCHum Mol Genet 23:6223-6234 (2014)Cited in1Mapped to9
KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun.Goitre L., De Luca E., Braggion S., Trapani E., Guglielmotto M., Biasi F., Forni M., Moglia A., Trabalzini L., Retta S.F.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCFree Radic Biol Med 68:134-147 (2014)Mapped to11
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.Koscielny G., Yaikhom G., Iyer V., Meehan T.F., Morgan H., Atienza-Herrero J., Blake A., Chen C.K., Easty R.[...], Parkinson H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCNucleic Acids Res 42:D802-9 (2014)Mapped to99+
CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling.Faurobert E., Rome C., Lisowska J., Manet-Dupe S., Boulday G., Malbouyres M., Balland M., Bouin A.P., Keramidas M.[...], Albiges-Rizo C.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCJ Cell Biol 202:545-561 (2013)Mapped to25
EndMT contributes to the onset and progression of cerebral cavernous malformations.Maddaluno L., Rudini N., Cuttano R., Bravi L., Giampietro C., Corada M., Ferrarini L., Orsenigo F., Papa E.[...], Dejana E.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCNature 498:492-496 (2013)Mapped to9
Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.Zheng X., Xu C., Smith A.O., Stratman A.N., Zou Z., Kleaveland B., Yuan L., Didiku C., Sen A.[...], Kahn M.L.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCDev Cell 23:342-355 (2012)Mapped to76
Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.Boulday G., Rudini N., Maddaluno L., Blecon A., Arnould M., Gaudric A., Chapon F., Adams R.H., Dejana E., Tournier-Lasserve E.View abstractCategoryFunctionSourceMGI: 1930618PubMedEurope PMCJ Exp Med 208:1835-1847 (2011)Mapped to19
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.Chan A.C., Drakos S.G., Ruiz O.E., Smith A.C., Gibson C.C., Ling J., Passi S.F., Stratman A.N., Sacharidou A.[...], Li D.Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCJ Clin Invest 121:1871-1881 (2011)Mapped to28
A novel mouse model of cerebral cavernous malformations based on the two- hit mutation hypothesis recapitulates the human disease.McDonald D.A., Shenkar R., Shi C., Stockton R.A., Akers A.L., Kucherlapati M.H., Kucherlapati R., Brainer J., Ginsberg M.H.[...], Marchuk D.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1930618PubMedEurope PMCHum Mol Genet 20:211-222 (2011)Mapped to16