A0A0G0Q4Z1 · A0A0G0Q4Z1_9BACT

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site72Zn2+ 1 (UniProtKB | ChEBI)
Binding site111Zn2+ 1 (UniProtKB | ChEBI)
Binding site210Zn2+ 2 (UniProtKB | ChEBI)
Binding site213Zn2+ 3 (UniProtKB | ChEBI)
Binding site247Zn2+ 2 (UniProtKB | ChEBI)
Binding site260Zn2+ 3 (UniProtKB | ChEBI)
Binding site262Zn2+ 3 (UniProtKB | ChEBI)
Binding site292Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      UT63_C0044G0008

Organism names

Accessions

  • Primary accession
    A0A0G0Q4Z1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-310Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    35,012
  • Last updated
    2015-07-22 v1
  • Checksum
    0B672794CAC970A5
MSIIYLMKLGAHLSISGGLDKAIENVVNIGGNCLQIFSTSPRMWKNPSVTEEMVERFKTAKEKFNIDPVYFHATYLISLGENGRVGQLSKDFLIAELSVAAKLGVRGSIVHLGSFKDGIGEKKQIHNQQTVLEEVVLEPSAGLHPVDIDGTIQNKYSVLVGNILQILDNTPKETLFMIENAGNRKIGLKLEEISHIIKSVGSPRFRVCLDTCHLHAAGYDIKTEEKLDAFLNEFDKLVGLDRLELFHINDSKDLFGSLRDRHENIGEGHIGLEPFRVLLNHPKTKNLSLIIETPGFENKGPDKKNLDILKELII

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LBXN01000044
EMBL· GenBank· DDBJ
KKR32441.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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