A0A0G0CZ33 · A0A0G0CZ33_9BACT

Function

function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for dna binding, site, active site.

TypeIDPosition(s)Description
DNA binding31-51H-T-H motif
Site89-90Cleavage; by autolysis
Active site125For autocatalytic cleavage activity
Active site163For autocatalytic cleavage activity
Active site289

GO annotations

AspectTerm
Molecular FunctionDNA (cytosine-5-)-methyltransferase activity
Molecular FunctionDNA binding
Molecular Functionserine-type endopeptidase activity
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological ProcessDNA restriction-modification system
Biological Processmethylation
Biological Processnegative regulation of DNA-templated transcription
Biological Processproteolysis
Biological ProcessSOS response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    LexA repressor
  • EC number

Gene names

    • Name
      lexA
    • ORF names
      UR90_C0033G0005

Organism names

Accessions

  • Primary accession
    A0A0G0CZ33

Proteomes

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-67LexA repressor DNA-binding
Domain82-196Peptidase S24/S26A/S26B/S26C

Sequence similarities

Belongs to the peptidase S24 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    60,419
  • Last updated
    2015-07-22 v1
  • Checksum
    36C320813935C7B7
MANTKPLTKKQKQVLDFVKDYISENGISPTIEEIRKKLKLRAVSTIHEHLNTLKTKGYLLKDENSARSIMPNKEIKKIIEIPIIGRIAAGEPIDVIENYFGTVSIINNDFKNIKDYYALRVMGNSMIDEGIFDGDTVIIKKQSVAENGQTVVAIIDDEQATLKKLYRENGKFRLQPRNPNIKPLFRTDVEIRGIVIQVISNINNKPEVRLEKKIKHRFKTIDLFAGIGGIRIGFERAGFETVFANDFDQQCKTTYDLNFAKSKLIVEDIRKVGINDLPKFDFLLGGFPCQAFSIAGYRQGFNDEKGRGNLFFDIARIIEARRPEGFLLENVKNLKSHDEGKTFKIIQETLENLGYHLNIKVLNSMEYGNIPQNRERVYIVGFKNKNYSDRFEFPNPIKLTVKITDLLETNVPEKYYYNGKPLFKKLKDFVKEEGRVYQWRRKYVRENKSGVCPTLTANMGTGGHNVPIIKDKKGIRKLTPRECALIQGFPIDYKIPILADSALYKQFGNSVSVPVIEAVGKQMMKAME

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LBQY01000033
EMBL· GenBank· DDBJ
KKP86298.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp