A0A0G0CZ33 · A0A0G0CZ33_9BACT
- ProteinLexA repressor
- GenelexA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids528 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Catalytic activity
- a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for dna binding, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 31-51 | H-T-H motif | ||||
Sequence: IEEIRKKLKLRAVSTIHEHLN | ||||||
Site | 89-90 | Cleavage; by autolysis | ||||
Sequence: AG | ||||||
Active site | 125 | For autocatalytic cleavage activity | ||||
Sequence: S | ||||||
Active site | 163 | For autocatalytic cleavage activity | ||||
Sequence: K | ||||||
Active site | 289 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | DNA (cytosine-5-)-methyltransferase activity | |
Molecular Function | DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | DNA repair | |
Biological Process | DNA replication | |
Biological Process | DNA restriction-modification system | |
Biological Process | methylation | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | SOS response |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLexA repressor
- EC number
Gene names
Organism names
- Taxonomic lineageBacteria
Accessions
- Primary accessionA0A0G0CZ33
Proteomes
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-67 | LexA repressor DNA-binding | ||||
Sequence: KPLTKKQKQVLDFVKDYISENGISPTIEEIRKKLKLRAVSTIHEHLNTLKTKGYLLKDENSAR | ||||||
Domain | 82-196 | Peptidase S24/S26A/S26B/S26C | ||||
Sequence: PIIGRIAAGEPIDVIENYFGTVSIINNDFKNIKDYYALRVMGNSMIDEGIFDGDTVIIKKQSVAENGQTVVAIIDDEQATLKKLYRENGKFRLQPRNPNIKPLFRTDVEIRGIVI |
Sequence similarities
Belongs to the peptidase S24 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length528
- Mass (Da)60,419
- Last updated2015-07-22 v1
- Checksum36C320813935C7B7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LBQY01000033 EMBL· GenBank· DDBJ | KKP86298.1 EMBL· GenBank· DDBJ | Genomic DNA |