A0A0G0BFN9 · A0A0G0BFN9_9BACT

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60carbamoyl phosphate (UniProtKB | ChEBI)
Binding site61carbamoyl phosphate (UniProtKB | ChEBI)
Binding site89L-aspartate (UniProtKB | ChEBI)
Binding site110carbamoyl phosphate (UniProtKB | ChEBI)
Binding site138carbamoyl phosphate (UniProtKB | ChEBI)
Binding site141carbamoyl phosphate (UniProtKB | ChEBI)
Binding site171L-aspartate (UniProtKB | ChEBI)
Binding site233L-aspartate (UniProtKB | ChEBI)
Binding site272carbamoyl phosphate (UniProtKB | ChEBI)
Binding site273carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • ORF names
      UR63_C0004G0017

Organism names

Accessions

  • Primary accession
    A0A0G0BFN9

Proteomes

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-150Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain157-308Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    597
  • Mass (Da)
    68,285
  • Last updated
    2015-07-22 v1
  • Checksum
    98F8AB7E492EC33F
MIKNKFYQRDILSANQFTRTDIENIFRVASEMEKIVGLHGHADILKGKVMTALFYEPSSRTFSSFVTAIQRLGGGFIPIHGVTNTSVTKGESLSDTIKAFSKYADIIVMRNPQVGAAKIAARFSDRPVINAGDGIGEHPTQGLLDIFTIYKRHKKIDGLTITMVGDMKNGRTIHSLSQFLSQFNRITIRFVSPKELQPQKELINKLKKNNVKISFHTDLTNILSDSDVLYVTRVQKERFKDLKLYEKLKHRYVITPKELKKMKKTAIILHPLPRVGEISASVDSDPRAVYLKEEMKNGLFVRMALLALVLRKEDITNFFTDDLFLTLNSKAIHSDPIYTYKLFKKELGSADSYFLAKSLGPESFHFSTNNMRFSEFKKMYLKMLFSPMLSEDKSTLIINEKNFRLKHGESGRNTTNIYLNHRVPLFNDLWDKKLLVKLLEMFIHKNILSHGSIYGIVAISSSSSPEITAAMHENSPHSTLRAVMLPRNLINKEKGTHEPIYGNIDVNLPWIFIDDVFTSGETLGENHDLFKKNISKKADVATYGVTLVNRNPKITDKFMSTTNMKIFSLVTLDDILKYHWKHFSTLQKKLINKERHL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LBPX01000004
EMBL· GenBank· DDBJ
KKP68279.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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