A0A0F7ZD23 · A0A0F7ZD23_CROAD
- ProteinAutophagy-related protein 9
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids851 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)
- a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | mitochondrion | |
Cellular Component | phagophore assembly site membrane | |
Biological Process | autophagy of mitochondrion | |
Biological Process | lipid transport | |
Biological Process | protein localization to phagophore assembly site |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 9
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Crotalus
Accessions
- Primary accessionA0A0F7ZD23
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Mitochondrion membrane ; Multi-pass membrane protein
Preautophagosomal structure membrane ; Multi-pass membrane protein
Recycling endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 74-95 | Helical | |||
Transmembrane | 127-145 | Helical | |||
Transmembrane | 291-315 | Helical | |||
Transmembrane | 369-395 | Helical | |||
Transmembrane | 407-426 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 660-697 | Disordered | |||
Region | 744-784 | Disordered | |||
Compositional bias | 757-781 | Polar residues | |||
Region | 796-851 | Disordered | |||
Compositional bias | 830-851 | Basic and acidic residues | |||
Sequence similarities
Belongs to the ATG9 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length851
- Mass (Da)96,471
- Last updated2015-07-22 v1
- Checksum485BF77B2315F169
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 757-781 | Polar residues | |||
Compositional bias | 830-851 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GBEX01000337 EMBL· GenBank· DDBJ | JAI14223.1 EMBL· GenBank· DDBJ | mRNA |