A0A0F7TQ80 · A0A0F7TQ80_PENBI

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      PMG11_05842

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MG11
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium

Accessions

  • Primary accession
    A0A0F7TQ80

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane48-67Helical
Transmembrane120-141Helical
Transmembrane148-166Helical
Transmembrane213-235Helical
Transmembrane270-291Helical
Transmembrane311-332Helical
Transmembrane339-359Helical
Transmembrane365-384Helical
Transmembrane405-422Helical
Transmembrane434-458Helical
Transmembrane497-518Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-461Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    526
  • Mass (Da)
    57,295
  • Last updated
    2015-07-22 v1
  • Checksum
    B44BECA08AF5F5CD
MMTDKEVVSKSVMDVVSTPASDEDLNTPVVSDKQLVTQSDDGKKAPPLTAKLFAVVLISCISFGSHWSSGVTGAMKSTIKKQMHINNVQFSLLEASEDFMATLLLIPSGLVTDRVGGAEMIVYGNIVYTIGSILVAAATTVRSFNFMIGGRVILALGDIATQIAQYKMFSSWFAPSNGFASTLGFELAIGKIGGFVGKSTANVIAKKTGNFAWVFWTAVFMNLFTNAATAVFWFFSRYCNRHYDGRRDTATNERLTERNKKFELQKVFQLPWMFWAVLAFSLFQTSTASTFSQNATELAEQRFDVDSIQAGWYSSLSQYAGFFLVPCLGVFIDVLGHRASVLFTCGLGMFLSMVLLNFAPSRAGTGASFGIYAIAVSMGPTSIIDSIRTTLWHQSVFGSAYSLKVTMNNAMNIIIRIIAGALQDADDNSYRRVVQVYLFLAAASLVVGSAILLGSFLTNNLGLLQWTRHKRLTSGAEIIQGLKERSLVAHAQRTRRVSVGCFGGLLLLIIGGWVAYIWGAVTGHNS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CDHK01000005
EMBL· GenBank· DDBJ
CEJ57137.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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