A0A0F7S9R7 · A0A0F7S9R7_9BASI

  • Protein
    Lon protease homolog, mitochondrial
  • Gene
    SSCI49150.1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

112081002003004005006007008009001,0001,1001,200
Type
IDPosition(s)Description
Binding site640-647ATP (UniProtKB | ChEBI)
Active site1073
Active site1116

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrion organization
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Gene names

    • Name
      SSCI49150.1
    • Synonyms
      PIM1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Ustilaginomycetes > Ustilaginales > Ustilaginaceae > Sporisorium

Accessions

  • Primary accession
    A0A0F7S9R7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-21Disordered
Compositional bias96-123Basic and acidic residues
Region96-148Disordered
Compositional bias124-144Polar residues
Domain155-487Lon N-terminal
Region232-256Disordered
Compositional bias241-256Basic and acidic residues
Region273-296Disordered
Region335-372Disordered
Region854-947Disordered
Compositional bias875-889Polar residues
Compositional bias897-922Polar residues
Domain981-1168Lon proteolytic
Region1179-1208Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,208
  • Mass (Da)
    129,923
  • Last updated
    2015-07-22 v1
  • Checksum
    8576E07F4AE6A3A7
MIPSQRYAAGNAARWRTSASNAATMSSRRLASFSSTAAAATARKSTASRFAHARIPLSADVNAAATSFASIPARSLFTSSPQYLPRMKKLERMLKEGEEHDGEEHEVEKEHEPRKEPEESEAKAESSSSSSSSGARSATGGAPASGSVPSVYPQVLALPITRRPLFPGFYKAVVIKNQAVCAAIKESLKRGQPYIGAFLLKDEEEDADVITDLSKVHKVGVFAQVTSLFPVQGGGQTGGSKKGKEGEDKSDDEEGITAVLYPHRRIRIDELITPTGQTIPSPPPGTEGAGPANPISDEAANEAVKAASIAKVHEIQQEARDDGILPEVNDASAAHLQQNAPPSPPAAVEGQSDAEGDAASTDGQDMPSHSAPFQTSFLQDYAVSLVNVTNLAAAPYDKRNDQYIRAVMSELISVFKDIAQLNPLFRDQIANFSISQGAGNVFEEPEKLADFAAAVSTGEVGELQAVLEALDIRERLQKALVVLKKELMNAQLQSKISKDVESKIQKRQREYYLMEQLKGIKKELGIESDGKDKMVEKFREKAGELNMPEAVRKVFDEELNKLQTLEPAASEFNVTRGYLDWLTSIPWGVHSPENYSISNATGVLDEDHYGLSDVKDRILEFLAVGKLKGTVEGKIICLVGPPGVGKTSIGKSIARAVERQFFRFSVGGLSDVAEIKGHRRTYVGAMPGKAIQALKKVGTENPLILIDEVDKIGRGHNGDPSSALLEMLDPEQNGSFLDHYMDVPVDLSRVLFVCTANTLETIPQPLLDRMEVMEVSSYTADEKRHIARGYLAPQAKEASGLQDANIELPDEMIDFLIKHHARESGVRGLRKLLEKVYRKIAFEIVKEHGESVFPEPKEGELASAKTEAASAVPAGAADSTTQSVTPPDVDGQVAESKETPSPFTEPSASTSEAETSPDSQPKQDGKVPGKEAAPEAPAKVTTEKRQPMAVPKNVKVVITIDSLRKYLGPPVYHKDRLYTSAMPAGVSTGLGYLGNGSGSLMPIETTIMPGKGGLQLTGKLGDVIKESALIALSWMKTNAYELGIVADAKEQLLENKDVHLHMPEGAIGKEGPSAGVAFTVSLTSLLTNRSVAPTLAMTGEVSLRGMVLPVGGLKEKLLAAHRAGITKLILPAQNQPNVEADVPKAVLDDLEVHYVNNVWSALNHAFGEGPWTAKAKEMEELERQESTVPAAAKETIKQDGASQDQPVN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias96-123Basic and acidic residues
Compositional bias124-144Polar residues
Compositional bias241-256Basic and acidic residues
Compositional bias875-889Polar residues
Compositional bias897-922Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CCFA01002904
EMBL· GenBank· DDBJ
CDW98179.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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