A0A0F7QHH0 · A0A0F7QHH0_URSTH
- ProteinPhosphotransferase
- GeneHK2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids173 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- ATP + D-fructose = ADP + D-fructose 6-phosphate + H+This reaction proceeds in the forward direction.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.
Carbohydrate metabolism; hexose metabolism.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | ATP binding | |
Molecular Function | D-glucose binding | |
Molecular Function | fructokinase activity | |
Molecular Function | glucokinase activity | |
Biological Process | glucose metabolic process | |
Biological Process | glycolytic process | |
Biological Process | intracellular glucose homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphotransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Ursidae > Ursus
Accessions
- Primary accessionA0A0F7QHH0
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Mitochondrion outer membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-173 | Hexokinase N-terminal | ||||
Sequence: LLEISKRFRKEMEKGLGATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQKVEMENQIYAIPEDLMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCVQTKLDESFLVSWTKGFKSSGVEGKDVVTLIRKAIQRRGDFDIDIVAVVN |
Sequence similarities
Belongs to the hexokinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length173
- Mass (Da)19,395
- Last updated2015-07-22 v1
- Checksum46233E055121D9B2
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: L | ||||||
Non-terminal residue | 173 | |||||
Sequence: N |