A0A0F7PSB9 · A0A0F7PSB9_9LACO

Function

function

Catalyzes the conversion of dihydroorotate to orotate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site28FMN (UniProtKB | ChEBI)
Binding site53substrate
Binding site53-54FMN (UniProtKB | ChEBI)
Binding site77-81substrate
Binding site137FMN (UniProtKB | ChEBI)
Binding site137substrate
Active site140Nucleophile
Binding site175FMN (UniProtKB | ChEBI)
Binding site201FMN (UniProtKB | ChEBI)
Binding site202-203substrate
Binding site227FMN (UniProtKB | ChEBI)
Binding site253-254FMN (UniProtKB | ChEBI)
Binding site275-276FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondihydroorotate dehydrogenase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase
  • EC number
  • Short names
    DHOD
    ; DHODase
    ; DHOdehase

Gene names

    • Name
      pyrD
    • ORF names
      LsR_00202

Organism names

Accessions

  • Primary accession
    A0A0F7PSB9

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-296Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    319
  • Mass (Da)
    33,719
  • Last updated
    2015-07-22 v1
  • Checksum
    A256EA2CF4049799
MEEFIMETKKLAVSLPGLELKNPIMPASGTFGFGDVPSANKYSLDTLGALVIKTTTPEARTGNPDPKISVIEDGVLNAVGLTNPGVDVVVSEKLPALREKYPELPIIGSVGGATEDDYVEVATKLSQSGMVNALELNISCPNVHEGGMAFGTVPEVAERLTKKVKEVSTVPVYVKLSPNVTDIVAIAKAVERGGADGISMINTVLGMHIDVASGKPVLGNIMGGLSGKAVKAIAIRMIYQVSQNTDLPIIGMGGVETVDDVLEMYMAGASAVAVGTAHFHDSMICPHLIEELPKRMEELGIESLEELRLNVKKRGAFKL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011403
EMBL· GenBank· DDBJ
AKI03753.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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