A0A0F7PSB9 · A0A0F7PSB9_9LACO
- ProteinDihydroorotate dehydrogenase
- GenepyrD
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate.
Catalytic activity
- (S)-dihydroorotate + A = orotate + AH2
Cofactor
Note: Binds 1 FMN per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 28 | FMN (UniProtKB | ChEBI) | |||
Binding site | 53 | substrate | |||
Binding site | 53-54 | FMN (UniProtKB | ChEBI) | |||
Binding site | 77-81 | substrate | |||
Binding site | 137 | FMN (UniProtKB | ChEBI) | |||
Binding site | 137 | substrate | |||
Active site | 140 | Nucleophile | |||
Binding site | 175 | FMN (UniProtKB | ChEBI) | |||
Binding site | 201 | FMN (UniProtKB | ChEBI) | |||
Binding site | 202-203 | substrate | |||
Binding site | 227 | FMN (UniProtKB | ChEBI) | |||
Binding site | 253-254 | FMN (UniProtKB | ChEBI) | |||
Binding site | 275-276 | FMN (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase
- EC number
- Short namesDHOD ; DHODase ; DHOdehase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Ligilactobacillus
Accessions
- Primary accessionA0A0F7PSB9
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-296 | Dihydroorotate dehydrogenase catalytic | |||
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)33,719
- Last updated2015-07-22 v1
- ChecksumA256EA2CF4049799
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011403 EMBL· GenBank· DDBJ | AKI03753.1 EMBL· GenBank· DDBJ | Genomic DNA |