A0A0F7LCA7 · A0A0F7LCA7_9APHY

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CGMCC5.249
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Polyporales > Polyporaceae > Ganoderma

Accessions

  • Primary accession
    A0A0F7LCA7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-37Helical
Transmembrane57-79Helical
Transmembrane100-118Helical
Transmembrane145-171Helical
Transmembrane183-210Helical
Transmembrane230-254Helical
Transmembrane266-287Helical
Transmembrane302-325Helical
Transmembrane337-358Helical
Transmembrane370-395Helical
Transmembrane407-426Helical
Transmembrane446-472Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-528Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    57,701
  • Last updated
    2015-07-22 v1
  • Checksum
    9B0C55C14C18BD62
MNNWLSSTNAKEIGTLYLIFSVFAGMIGTAFSVLIRLELSAPGVQVLQGDHQLFNVIITAHAFIMIFFMVMPALVGGFGNYLLPVQVGAPDMAFPRLNNISFWLLPPSLILLLLSALVENGAGTGWTVYPPLAGIQSHSGASVDLAIFSLHLAGVSSLLGAINFITTVLNMRTNGMSLHKLPLFVWAIFVTAILLLLSLPVLAGAITMLLTDRNFNTSFYDPAGGGDPILYQHLFWFFGHPEVYILIIPGFGIVSHVVSTFSGKPIFGYLGMVYAMFSIGILGFLVWSHHMFAVGLDVDTRAYFTAATMVIAVPTGIKIFSWLATLYGGSLRFTTPLLFTLGFLALFTIGGLTGVVLANASMDIALHDTYYVVAHFHYVLSMGAVFALFAGFYFWTPKIIGLTYNELLGKIHFWTLFVGVNLTFFPQHFLGISGMPRRIPDYPDAFAGWNAVSSLGSLISVVATVLFGYIIYDIFANGKAVNNNPWLVPSYFTSTNEFNNEAQTANTLEWTVQSPIPFHAFNILPVQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR109212
EMBL· GenBank· DDBJ
AKH60740.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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