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A0A0F7DBX6 · A0A0F7DBX6_9EURY

  • Protein
    dITP/XTP pyrophosphatase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14substrate
Binding site38Mg2+ (UniProtKB | ChEBI)
Active site67Proton acceptor
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site68substrate
Binding site142-145substrate
Binding site162substrate
Binding site167-168substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      GAH_00812

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 234
  • Taxonomic lineage
    Archaea > Euryarchaeota > Archaeoglobi > Archaeoglobales > Archaeoglobaceae > Geoglobus

Accessions

  • Primary accession
    A0A0F7DBX6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    183
  • Mass (Da)
    20,815
  • Last updated
    2015-07-22 v1
  • MD5 Checksum
    322B640BBC69CF7461A4CE4B8B7DA521
MGMKVRFITSNRGKFEELKEIGRGFGVDIEWVEMEYLEPQGSDLEFVARKSAEMLSGAVEPPFFIEDSGLFIDALHGFPGVYSSFVFKTIGNDGILKLMEGVEDRRARFVCVIAFSDGEQVRTFTGEVEGQIAREKRGEHGFGYDPIFEVDGRTFAEMGEKKNELSHRRRAAEKFFSWLAKNF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011267
EMBL· GenBank· DDBJ
AKG91856.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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