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A0A0F7CK29 · A0A0F7CK29_PAEDU

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

168350100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site207-214ATP (UniProtKB | ChEBI)
Binding site429Zn2+ (UniProtKB | ChEBI); catalytic
Active site430
Binding site433Zn2+ (UniProtKB | ChEBI); catalytic
Binding site505Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      VK70_22495

Organism names

Accessions

  • Primary accession
    A0A0F7CK29

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-26Helical
Transmembrane114-136Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain199-338AAA+ ATPase
Region613-683Disordered
Compositional bias645-672Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    683
  • Mass (Da)
    75,487
  • Last updated
    2015-07-22 v1
  • MD5 Checksum
    A5052667F0DDB9D7207607E5C25348DF
MNRFIRNSGFYLILFLVVVGIVQFVSNGNEAADFPRYDQLRQELKSNNVKDLTVQFEGNAFNVTGSYKEKPEWAKSQSFSTYIPPTDAAIEELTAASQANNIPFVQKKMEGDSIWLTFLSSIIPLVIMFILFFFLFNQAQGGGGKVMNFGKSKARLYNEEKKRVTFEDVAGADEEKQELVEVVEFLKDPRKFAAVGARIPKGVLLVGPPGTGKTLLARAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGGNEGIIIVAATNRADILDPALLRPGRFDRQITVDRPDVKGREAVLKVHSRNKPLTKDVKLDVIAKRTTGFTGADLENLLNEAALLAARRNRKDISMREVDEAIDRVIVGTEKRSRVISDREKRIVAYHEAGHTIAGYFLEHADMVHKVTIIPRGRAGGYVIMLPKEDRMLVTKQELLDKVTGLLGGRVAEEMFIGEIGTGAYSDFQQATRIVRSMIMEYGMSEKLGPMQFGTSQGQVFLGRDIGHEQNYSDSIAYEIDQEMQRFINECYERCRELLKKHSKEMHLIAGTLLEKETLELEQIKELIEQGYLTEDGKPVDGQSLANEGAEPIIDPIGDVKVRIQGKTSEPQATLGDSPKDIPNNPQQDGESGNDENKGGGAGLS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias645-672Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011114
EMBL· GenBank· DDBJ
AKG36941.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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