A0A0F6T1J9 · A0A0F6T1J9_DROME

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

148150100150200250300350400450
Type
IDPosition(s)Description
Binding site11-16NADP+ (UniProtKB | ChEBI)
Binding site34-36NADP+ (UniProtKB | ChEBI)
Binding site76-78NADP+ (UniProtKB | ChEBI)
Binding site104NADP+ (UniProtKB | ChEBI)
Binding site104substrate; ligand shared between dimeric partners; in other chain
Binding site130-132substrate; ligand shared between dimeric partners; in other chain
Active site184Proton acceptor
Binding site187-188substrate; ligand shared between dimeric partners; in other chain
Active site191Proton donor
Binding site192substrate; ligand shared between dimeric partners; in other chain
Binding site259substrate; ligand shared between dimeric partners; in other chain
Binding site286substrate; ligand shared between dimeric partners; in other chain
Binding site445substrate; ligand shared between dimeric partners
Binding site451substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate metabolic process
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • Name
      Pgd

Organism names

  • Taxonomic identifier
  • Strain
    • NL13
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A0A0F6T1J9

Organism-specific databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain180-4686-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    52,431
  • Last updated
    2015-07-22 v1
  • Checksum
    8C49EDF197D0F6EC
MSGQADIALIGLAVMGQNLILNMDEKGFVVCACNRTVAKVKEFLANEAKDTKVIGADSLEDMVSKLKSPRKVMLLVKAGSAVDDFIQQLVPLLSAGDVIIDGGNSEYQDTSRRCDELAKLGLLFVGSGVSGGEEGARHGPSLMPGGHEAAWPLIQPIFQAICAKADGEPCCEWVGDGGAGHFVKMVHNGIEYGDMQLICEAYHIMQSLGLSADQMADEFGKWNSAELDSFLIEITRDILKYKDGKGYLLERIRDTAGQKGTGKWTAIAALQYGVPVTLIGEAVFSRCLSALKDERVQASSVLKGPSTKAQVANLTKFLDDIKHALYCAKIVSYAQGFMLMREAARENKWRLNYGGIALMWRGGCIIRSVFLGNIKDAYTSQPELSNLLLDDFFKKAIERGQDSWREVVANAFRWGIPVPALSTALSFYDGYRTAKLPANLLQAQRDYFGAHTYELLGQEGQFHHTNWTGTGGNVSASTYQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR024143
EMBL· GenBank· DDBJ
AKD42988.1
EMBL· GenBank· DDBJ
Genomic DNA
KR024143
EMBL· GenBank· DDBJ
AKD42989.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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