A0A0F6T1J9 · A0A0F6T1J9_DROME
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- GenePgd
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids481 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-16 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 34-36 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 76-78 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 104 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 104 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 130-132 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 184 | Proton acceptor | |||
Binding site | 187-188 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 191 | Proton donor | |||
Binding site | 192 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 259 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 286 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 445 | substrate; ligand shared between dimeric partners | |||
Binding site | 451 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate metabolic process | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA0A0F6T1J9
Organism-specific databases
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length481
- Mass (Da)52,431
- Last updated2015-07-22 v1
- Checksum8C49EDF197D0F6EC
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KR024143 EMBL· GenBank· DDBJ | AKD42988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR024143 EMBL· GenBank· DDBJ | AKD42989.1 EMBL· GenBank· DDBJ | Genomic DNA |