A0A0F5PD20 · A0A0F5PD20_9SPHN

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site187[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site194[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site197[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site203[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • ORF names
      WP12_08560

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SRS2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A0F5PD20

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-185HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    219
  • Mass (Da)
    24,194
  • Last updated
    2015-06-24 v1
  • MD5 Checksum
    7D61E98512EAD044736A675C45DE79E8
MKKADVFEFYRRLAENNPAPETELNYVNPYTLLVAVALSAQATDIGVNKATGPLFAKVTTPQQMLELGEDGLKQHIKTIGLFNMKARNVIAAAHILVEKYGGEVPQSREALEELPGVGRKTANVVMNTAFGAETIAVDTHIFRVSNRTGLAPGKNVLQVELKLEKVTPQLFLQGAHHWLILHGRYICKARKPECWRCPVIDLCAFKPKTPAPKEKIISA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LARW01000075
EMBL· GenBank· DDBJ
KKC26377.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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