A0A0F5P5Y2 · A0A0F5P5Y2_9SPHN

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site135(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site139-141(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site243Plays an important role in substrate specificity
Binding site259(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      WP12_22355

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SRS2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A0F5P5Y2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue244N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain22-399Serine hydroxymethyltransferase-like
Region361-383Disordered

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    46,398
  • Last updated
    2015-06-24 v1
  • Checksum
    1EC9E5C1868D81F2
MSSNPAANLSDVQPDGFFTRGLAQADPAVFGGLQAEVTREKKQIELIASENIVSKAVLEAQGSVFTNKYAEGYPGKRYYQGCHPSDVVEQLAIDRAKQLFGCGFVNVQPHSGAQANGAVMLALTKPGDTIMGLSLDAGGHLTHGARAAMSGKWYNAIQYGVRPDDHRIDFDQVEALAREHKPTLIITGGSAYPRHIDFARFRAIADEVGAIFMVDMAHFAGLVAGGVHPTPFGHAHVVTTTTHKTLRGPRGGMIMTDDEAIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFKLYAAAVVENAKVLAARLKERGADLVSGGTDTHLALVDLRPIGVTGRDADEALERAGITCNKNGVPNDPLPPVKTSGIRVGSPAGTTRGFGPAEFRDIADMIADVLDGLAKNGPEGNGQTEAHVKERVEALCDRFPIYPEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LARW01000157
EMBL· GenBank· DDBJ
KKC23890.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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