A0A0F4ESW9 · A0A0F4ESW9_9MYCO

  • Protein
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • Gene
    rraA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site78-81substrate
Binding site100substrate
Binding site101Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • Name
      rraA
    • ORF names
      MLPM_0066

Organism names

  • Taxonomic identifier
  • Strain
    • Mx1-22A
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A0F4ESW9

Proteomes

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    16,291
  • Last updated
    2015-06-24 v1
  • Checksum
    70C29F7ECFC9627F
MTVLFRPTADLVDSIEADVRSCDLQFRQFGGCSEFAGQISTVRCFQDNALLKLVLAQASAGGVLVVDGASSLHTALVGDVIAKLARSNGWAGLIVNGAVRDSAALRGIDIGIKALGTNPRKSTKIGDGERDVEVNLGGVTFVPGEVAYSDDDGIVVV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRPY01000003
EMBL· GenBank· DDBJ
KJX75898.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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