A0A0F4EQQ2 · A0A0F4EQQ2_9MYCO

  • Protein
    Multifunctional 2-oxoglutarate metabolism enzyme
  • Gene
    sucA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentoxoglutarate dehydrogenase complex
Molecular Function2-hydroxy-3-oxoadipate synthase activity
Molecular Function2-oxoglutarate decarboxylase activity
Molecular Functiondihydrolipoyllysine-residue succinyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionoxoglutarate dehydrogenase (succinyl-transferring) activity
Molecular Functionthiamine pyrophosphate binding
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional 2-oxoglutarate metabolism enzyme
  • EC number
  • Alternative names
    • 2-hydroxy-3-oxoadipate synthase
    • 2-oxoglutarate carboxy-lyase
    • 2-oxoglutarate decarboxylase
    • Alpha-ketoglutarate decarboxylase
    • Alpha-ketoglutarate-glyoxylate carboligase

Gene names

    • Name
      sucA
    • ORF names
      MLPM_1095

Organism names

  • Taxonomic identifier
  • Strain
    • Mx1-22A
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A0F4EQQ2

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

Type
IDPosition(s)Description
Region39-108Disordered
Compositional bias44-62Polar residues
Coiled coil798-825
Domain888-1087Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,238
  • Mass (Da)
    137,197
  • Last updated
    2015-06-24 v1
  • Checksum
    89EC5C17EBA48CDB
MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYNPESTTEPVLTDPTSTDKQPSAAPQVKLAAVAEPAASRAKPAASPTVTKGTTAGPTAAPAEIGTTPTAEGDELQVLRGAAATVVKNMSASLDVPTATSVRAIPAKLMIDNRTVINNQLKRNRGGKISFTHLLGYALVQAVKKFPNINRHYAEIGGKPAAVTPAHTNLGLAIDLQGKDSRRSLVVAGVKRCEELRFAQFVTACEDIVRRARDGKLTAEDFADVTISLTNPGTIGTVHSVPRLMTGQGAIIGVGAMEYPAEFQGASAERVAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHEMMLSDNFWDEIFRELSIPYLPVRWRTDNPDSIVDKNARVMELIAAYRNRGHLMADIDPLRLDNTRFRSHPDLDVLTHGLTLWDLDRVFKVNGFGGWEYKKLRDVLGLLRDVYCRHIGVEYTHILDPEQQEWLQQRVETKHVKPTVAEQKYILSKLNAAEAFETFLHTKYVGQKRFSLEGAESVIPMMDAAIDQCAKHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPAMAHNSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLNKDADGNQDEAFSVVPMMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEHSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVAKLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDTKRGARKSYTEALIGRGDISLKEAEDALRDYQGQLERVFNEVRDLEKHGVQPSESVESDQMIPAGLSTAVDKALLARIGDAFLAIPEGFTVHPRVQPVLEKRREMAYEGKIDWAFAELLALGSLVAEGKLVRLSGQDTKRGTFSQRHSVIIDRHTGEEFTPLQLLANNPDGSPTGGKFLVYNSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFINSGEAKWGQLSTVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTFAMPSTPSNYFHLLRRHALDGIKRPLIVFTPKSMLRNKAAVSDIKDFTEIKFRSVLEEPTYEDSIDDRSKVTRVLLTCGKLYYELAARKIKDNRDDVAIVRIEQLAPLPRRRLSETLDRYENAKEFFWVQEEPANQGAWPRFGLELPELLPRLTGIKRISRRAMSAPSSGSPKVHAVEQQEILDTAFS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias44-62Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRPY01000044
EMBL· GenBank· DDBJ
KJX75286.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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