A0A0F4EQN9 · A0A0F4EQN9_9MYCO

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site80Mg2+ (UniProtKB | ChEBI)
Binding site81Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site82Mg2+ (UniProtKB | ChEBI)
Binding site84Mg2+ (UniProtKB | ChEBI)
Binding site97Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site104Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • ORF names
      MLPM_1264

Organism names

  • Taxonomic identifier
  • Strain
    • Mx1-22A
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A0F4EQN9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-105Phosphoribosyl-AMP cyclohydrolase

Sequence similarities

Belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    12,522
  • Last updated
    2015-06-24 v1
  • Checksum
    806D80D0C1B2FCC9
MTLDPDIAARLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAEQWIKGATSGNTQHVHSVRLDCDGDTVLLTVDQVGGACHTGAHSCFDAAMLLAPQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRPY01000050
EMBL· GenBank· DDBJ
KJX75218.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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