A0A0F2P7S6 · A0A0F2P7S6_9FIRM
- ProteinUrocanate hydratase
- GenehutU
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids674 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalytic activity
- 4-imidazolone-5-propanoate = H2O + trans-urocanate
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | urocanate hydratase activity | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUrocanate hydratase
- EC number
- Short namesUrocanase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Peptococcaceae
Accessions
- Primary accessionA0A0F2P7S6
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 88-214 | Urocanase N-terminal | ||||
Sequence: ISAKPITEHQGNCTEGRAFQVMIDNNLDFEVALYPYELVTYGETGSVCQNWMQYRLIKKYLEVMTDHQTLVMESGHPLGLFPSKPEAPRVIITNALMVGMFDNQEDWEIAQEMGVSNYGQMTAGGWM | ||||||
Domain | 217-440 | Urocanase Rossmann-like | ||||
Sequence: GPQGIVHGTYNTILIAGRAKLGIPEDGDLSGHMFISSGLGGMSGAQPKAVEIARGVGIIAEVDYSRIKTRHDQGWVGMMSDDLDEIFRTAAEYLAKKEPLSIAYHGNIVDLLEYVVQNNIKVELLSDQTSCHVAYAGGYCPQGVTFDERTRLLAEDQSQFRRLVDKSLRRQYELIKIMVERGTYFFDYGNAFLKAVYDAGVQEIAANGVDDKDGFIWPSYVEDI | ||||||
Domain | 444-640 | Urocanase C-terminal | ||||
Sequence: ELFDYGYGPFRWVCLSGKPEDLAQTDRAAMDCIDPAGRYQDRDNYIWIRDAQQNKLVVGSQARILYQDAGGRVKIALKFNEMVRNGEIGPVMLGRDHHDTGGTDSPFRETANIKDGSNVMADMATQCFAGNAARGMSLVSLHNGGGVGIGKAINGGFGLVLDGTARVDNIIKSAMLWDVMGGVARRSWARNDNSITT |
Sequence similarities
Belongs to the urocanase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length674
- Mass (Da)74,817
- Last updated2015-06-24 v1
- Checksum54CAE97617498CB3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LADP01000046 EMBL· GenBank· DDBJ | KJS10313.1 EMBL· GenBank· DDBJ | Genomic DNA |