A0A0F2P7S6 · A0A0F2P7S6_9FIRM

Function

function

Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Note: Binds 1 NAD+ per subunit.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site207NAD+ (UniProtKB | ChEBI)
Binding site277NAD+ (UniProtKB | ChEBI)
Binding site282NAD+ (UniProtKB | ChEBI)
Binding site404NAD+ (UniProtKB | ChEBI)
Binding site589NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionurocanate hydratase activity
Biological ProcessL-histidine catabolic process to glutamate and formamide
Biological ProcessL-histidine catabolic process to glutamate and formate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Urocanate hydratase
  • EC number
  • Short names
    Urocanase
  • Alternative names
    • Imidazolonepropionate hydrolase

Gene names

    • Name
      hutU
    • ORF names
      VR67_18560

Organism names

Accessions

  • Primary accession
    A0A0F2P7S6

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain88-214Urocanase N-terminal
Domain217-440Urocanase Rossmann-like
Domain444-640Urocanase C-terminal

Sequence similarities

Belongs to the urocanase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    674
  • Mass (Da)
    74,817
  • Last updated
    2015-06-24 v1
  • Checksum
    54CAE97617498CB3
MLTNREITGAMTIKLDQVPEKTPAFVPGIRRAPNRGFRLTPAQTKVALKNALRYVPEAYHAELAPEFLNELLTRGRIYGYRFRPEGRISAKPITEHQGNCTEGRAFQVMIDNNLDFEVALYPYELVTYGETGSVCQNWMQYRLIKKYLEVMTDHQTLVMESGHPLGLFPSKPEAPRVIITNALMVGMFDNQEDWEIAQEMGVSNYGQMTAGGWMYIGPQGIVHGTYNTILIAGRAKLGIPEDGDLSGHMFISSGLGGMSGAQPKAVEIARGVGIIAEVDYSRIKTRHDQGWVGMMSDDLDEIFRTAAEYLAKKEPLSIAYHGNIVDLLEYVVQNNIKVELLSDQTSCHVAYAGGYCPQGVTFDERTRLLAEDQSQFRRLVDKSLRRQYELIKIMVERGTYFFDYGNAFLKAVYDAGVQEIAANGVDDKDGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGKPEDLAQTDRAAMDCIDPAGRYQDRDNYIWIRDAQQNKLVVGSQARILYQDAGGRVKIALKFNEMVRNGEIGPVMLGRDHHDTGGTDSPFRETANIKDGSNVMADMATQCFAGNAARGMSLVSLHNGGGVGIGKAINGGFGLVLDGTARVDNIIKSAMLWDVMGGVARRSWARNDNSITTSMEFNRNFAGSGHITLPYLADDELVDRLVTTALK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LADP01000046
EMBL· GenBank· DDBJ
KJS10313.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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