A0A0F2LQQ3 · A0A0F2LQQ3_9CREN

  • Protein
    S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
  • Gene
    taw1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site35[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site48[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site61[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site71[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site75[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site78[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular FunctiontRNA-4-demethylwyosine synthase activity
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
  • EC number
  • Alternative names
    • tRNA wyosine derivatives biosynthesis protein Taw1

Gene names

    • Name
      taw1
    • Synonyms
      twy1
    • ORF names
      TQ35_005870
      , TQ35_03360

Organism names

Accessions

  • Primary accession
    A0A0F2LQQ3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-304Radical SAM core

Sequence similarities

Belongs to the TYW1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    358
  • Mass (Da)
    41,672
  • Last updated
    2015-06-24 v1
  • Checksum
    520FBC5BBB5AF075
METPKFRIDTLSRIVDEMEKEKYHIIGSHSAYKKCYWTHKALTAHRYCYKGKFYGIESHRCVQMTPVAAWCWFRCIHCWRLEPEDIGLEWDETKMPVSDDPEYIAERSIEEHVKAVSGYYGREGVDKELVKAASRPAHVAISLTGEPTLYERLGELIKEYHKRGMTTFLVTSGVRPDILASLEEEPTQLFVSLQAPNERKHKLINRPIVANSWNLVMETLRMMPSFSSPTVIRMTMIKGFNMSEDDAREFAKLIEISMPTYIEVKAYMHVGPSTYRLSRDAMPRHREIREFAELLAKYTGYKILSEHVPSRIVLLSRLDRPIQIGNAWTQKWDWRAKDKEDDIHGEYEEAELGCTEGT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JZWS01000019
EMBL· GenBank· DDBJ
KJR79154.1
EMBL· GenBank· DDBJ
Genomic DNA
JZWS02000004
EMBL· GenBank· DDBJ
MCL7344085.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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