A0A0E9NDD9 · A0A0E9NDD9_SAICN

Function

function

Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcatalytic step 2 spliceosome
Cellular ComponentSAGA-type complex
Molecular Functionmetal ion binding
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Biological Processprotein folding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    SAGA-associated factor 11

Gene names

    • ORF names
      G7K_2031-t1

Organism names

Accessions

  • Primary accession
    A0A0E9NDD9

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-27Disordered
Region196-325Disordered
Compositional bias200-220Polar residues
Domain445-599PPIase cyclophilin-type

Sequence similarities

Belongs to the SGF11 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    64,753
  • Last updated
    2015-06-24 v1
  • Checksum
    6CCE7BCBD357A941
MQLPVARVSQPPYVARRSNGGRARQSPFCHRYRHTKSSSASVPRYLKPVELGELGSGLTQHDLALTLLIYTSPHTMPSSGSGIPPPPPNSIPALSLSILHDLILDNLHDIALSAHTHAHTSRQICPTHNKPCRQFCSLPNKDIWGKDLVNGGKEGGAGGGGGSGAYVRCDICGREVAGSRFAPHLEKCLGLGGARRAASSSKKGSGTASPYTFATNSDASDDDFELSDASTAASGKSKKRKNPPIEKKSHVQKFKQASGGRGASPAVSERANGSGSWDGGGVEMERSRSEGTGGKTLPGKSDALTKAASRQRSTRAEMLEENEPRQEAIWTDPTTRVTHDCNISNNTTELQLRTPKERNIPALTTQALVALPKEESSCAGDMNGSVLILVLPTTTNAPPTNEEQKEVRIRVNPKRPVSETVVELKLKFVGCAERPWTTTENWTSKMGDVVLETSMGPVTVELYWDHAPRTCKNFAELAKRGYYHGVVFHRIIPDFMIQGGDPTGTGRGGSSIYGEKFADEIHPGLKHTGAGVLSMANAGPNSNGSQFFITLAPTPWLDGKHTIFGRVKEGMRTVQRLGLVRTGAADRPVEEVKIIKAGLVEQQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias200-220Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BACD03000011
EMBL· GenBank· DDBJ
GAO47833.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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