A0A0E4B7L7 · A0A0E4B7L7_9LABR
- Proteinaromatase
- Genecyp19a1a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids452 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- testosterone + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 17beta-estradiol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 383 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | female gonad development | |
Biological Process | response to estradiol |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namearomatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Labriformes > Labridae > Parajulis
Accessions
- Primary accessionA0A0E4B7L7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
Structure
Sequence
- Sequence statusFragment
- Length452
- Mass (Da)51,737
- Last updated2015-06-24 v1
- Checksum29250384D4448CFA
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB911712 EMBL· GenBank· DDBJ | BAR45421.1 EMBL· GenBank· DDBJ | mRNA |