A0A0E4B7L7 · A0A0E4B7L7_9LABR

Function

function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site383Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionaromatase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfemale gonad development
Biological Processresponse to estradiol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    aromatase
  • EC number
  • Alternative names
    • Cytochrome P-450AROM
    • Estrogen synthase

Gene names

    • Name
      cyp19a1a

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Labriformes > Labridae > Parajulis

Accessions

  • Primary accession
    A0A0E4B7L7

Subcellular Location

Membrane
; Peripheral membrane protein

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil188-222

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    452
  • Mass (Da)
    51,737
  • Last updated
    2015-06-24 v1
  • Checksum
    29250384D4448CFA
PIFLSGLGPLLSYLRFIWTGIGTASNFYSTKYGDIVRVWIDGEETLIFSRASAVHHVLKSSNYTSRFGSKQGLSCIGMNERGIIFNNNVPLWKKIRTYFTKALTGPGLLQTVEVCVSSTQSHLDGLESLDQVDVISLLRCTVVDISNRLFLDVPVNEKELMVKIHKYFDTWQTVLIKPDIYFKLDWIHQRHKMAAQELQDAIESLVEQKRREVEQAEKLDNINFTAELIFAQSHGELSAENVRQCVLEMVIAAPDTLSISLFFMLLLLKQHPDVELQLLQEIDTVVGDRQLQNGDLHKLPLLESFINECLRFHPVVDFTMRRALSDDIIEGYRVPKGTNIILNTGHMHRTEFFHKPNDFNLKNFEKNAPRRYFQPFGSGPRACVGKHIAMLMMKSILVTLLSQYSVCPHEGLTLDGLTQTNNLSQQPVEHHQENEPLGMRFLPRQRGCWENL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB911712
EMBL· GenBank· DDBJ
BAR45421.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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