A0A0E3Z6J5 · A0A0E3Z6J5_9ANNE
- ProteinNADH-ubiquinone oxidoreductase chain 2
- GeneND2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids185 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 2
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Clitellata > Oligochaeta > Crassiclitellata > Lumbricina > Lumbricidae > Lumbricinae > Lumbricus
Accessions
- Primary accessionA0A0E3Z6J5
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 50-70 | Helical | |||
Transmembrane | 90-112 | Helical | |||
Transmembrane | 124-145 | Helical | |||
Transmembrane | 165-184 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length185
- Mass (Da)20,256
- Last updated2015-06-24 v1
- MD5 Checksum03B70A31CBDAC52C56F2CBDFD74ECFE5
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 185 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP420669 EMBL· GenBank· DDBJ | AKC91556.1 EMBL· GenBank· DDBJ | Genomic DNA |