A0A0E3V5R4 · A0A0E3V5R4_9BACT
- ProteinUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- GenemurF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids441 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Catalytic activity
- ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H+ + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity | |
Molecular Function | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Cytophagia > Cytophagales > Cytophagaceae > Spirosoma
Accessions
- Primary accessionA0A0E3V5R4
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-65 | Mur ligase N-terminal catalytic | ||||
Sequence: AGVSTDTRRITPDCLFVALKGDTFDGNKFAEQALAAGARYAVVDDPEVAS | ||||||
Domain | 99-289 | Mur ligase central | ||||
Sequence: TGSNGKTTTKELIAAVLSKNYQLYATVGNLNNHIGVPLTLLALNEQHELAIVEMGANHQKEIELLCSIAQPTHGLITNVGKAHLEGFGGIEGVRKGKGELYDYLAQNAKTVFINSRDKTLTAMYRERLKAIRSETSFAEVIFYPAAESDQEPITLLSESPVVVYRDSSGHDVTTHLPGRYNFENMLAALAI | ||||||
Domain | 313-430 | Mur ligase C-terminal | ||||
Sequence: RSQHITKGTNTVLLDAYNANPSSMAAAIQQFAATPAKRKVVILGDMYELGPESEAEHTALGKLIAESKFDLVILAGKDMHYALGYLPKAYYFPDKFSLHNWLMDNPMTDTHILVKGSR |
Sequence similarities
Belongs to the MurCDEF family. MurF subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)48,176
- Last updated2015-06-24 v1
- ChecksumAABD08FCD6935727
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP010429 EMBL· GenBank· DDBJ | AKD53881.1 EMBL· GenBank· DDBJ | Genomic DNA |