A0A0E3P2S0 · A0A0E3P2S0_9EURY
- ProteinCoenzyme A biosynthesis bifunctional protein CoaBC
- GenecoaBC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids450 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalytic activity
- (R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN per subunit.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | phosphopantothenoylcysteine decarboxylase complex | |
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphopantothenate--cysteine ligase activity | |
Molecular Function | phosphopantothenoylcysteine decarboxylase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | pantothenate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoenzyme A biosynthesis bifunctional protein CoaBC
- Alternative names
Including 2 domains:
- Recommended namePhosphopantothenoylcysteine decarboxylase
- EC number
- Short namesPPC decarboxylase ; PPC-DC
- Alternative names
- Recommended namePhosphopantothenate--cysteine ligase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina
Accessions
- Primary accessionA0A0E3P2S0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-48 | Disordered | ||||
Sequence: MKPDRKNPNVSGPEPENSGQNGPDEAKLRDWTDRQNPDRTKAEKIHPT | ||||||
Region | 1-240 | Phosphopantothenoylcysteine decarboxylase | ||||
Sequence: MKPDRKNPNVSGPEPENSGQNGPDEAKLRDWTDRQNPDRTKAEKIHPTLWIQGQKNSSLAGKTIALGVTGSIGAVRVVELARELIRNGAEVHAVMTEAARHILHPDALHYATGNPVITELGGRVEHVEFCGFKGRADLLLIAPATANTIGKIAYGIDDTTVTSFATTALGSDVPLMVVPAMHESMYRHPAVVENVAKLKGWGVSMVGPKFAEGIAKIASNEEIVLEVERALGNRSLENRK | ||||||
Compositional bias | 26-45 | Basic and acidic residues | ||||
Sequence: AKLRDWTDRQNPDRTKAEKI | ||||||
Domain | 62-229 | Flavoprotein | ||||
Sequence: KTIALGVTGSIGAVRVVELARELIRNGAEVHAVMTEAARHILHPDALHYATGNPVITELGGRVEHVEFCGFKGRADLLLIAPATANTIGKIAYGIDDTTVTSFATTALGSDVPLMVVPAMHESMYRHPAVVENVAKLKGWGVSMVGPKFAEGIAKIASNEEIVLEVER | ||||||
Domain | 236-416 | DNA/pantothenate metabolism flavoprotein C-terminal | ||||
Sequence: LENRKVLITGGSTAESLDPIRILTNRASGKTGRELALEVYRCGADVTLVHRDRLGLAGIKEVFAESAEEMTEAVLSELEKGYDALISSAAIADYTAEPSPEKIKSGGEFVLKLKPTRKLIKECREKHPDLVIIGFKAETGVGRDELLKRAAATLKGTKLDLIAANDVGKGGMGTEENELYL | ||||||
Region | 241-450 | Phosphopantothenate--cysteine ligase | ||||
Sequence: VLITGGSTAESLDPIRILTNRASGKTGRELALEVYRCGADVTLVHRDRLGLAGIKEVFAESAEEMTEAVLSELEKGYDALISSAAIADYTAEPSPEKIKSGGEFVLKLKPTRKLIKECREKHPDLVIIGFKAETGVGRDELLKRAAATLKGTKLDLIAANDVGKGGMGTEENELYLLGKGEPRHISGNKRKLAACILEELTGILNSRQEP |
Sequence similarities
In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length450
- Mass (Da)48,442
- Last updated2015-06-24 v1
- Checksum571593F8FF0EF1E3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 26-45 | Basic and acidic residues | ||||
Sequence: AKLRDWTDRQNPDRTKAEKI |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP009506 EMBL· GenBank· DDBJ | AKB27668.1 EMBL· GenBank· DDBJ | Genomic DNA |