A0A0E3LTN2 · A0A0E3LTN2_METMZ

Function

function

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

Catalytic activity

  • Cleavage of peptide bonds with very broad specificity.
    EC:3.4.25.1 (UniProtKB | ENZYME | Rhea)

Activity regulation

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

Features

Showing features for active site.

121020406080100120140160180200
TypeIDPosition(s)Description
Active site10Nucleophile

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentproteasome core complex, beta-subunit complex
Molecular Functionthreonine-type endopeptidase activity
Biological Processproteasomal protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Proteasome subunit beta
  • EC number
  • Alternative names
    • 20S proteasome beta subunit
    • Proteasome core protein PsmB

Gene names

    • Name
      psmB
    • ORF names
      MSMAS_0620

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • S-6
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina

Accessions

  • Primary accession
    A0A0E3LTN2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for propeptide, chain.

Type
IDPosition(s)Description
PropeptidePRO_50050232101-9Removed in mature form; by autocatalysis
ChainPRO_502355641310-210Proteasome subunit beta

Keywords

Interaction

Subunit

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase T1B family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    210
  • Mass (Da)
    22,885
  • Last updated
    2015-06-24 v1
  • Checksum
    6223B44ED0943190
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGDAQQLVRLVSVESQLYKMRRNESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAIYSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVKEGLDLAIRAIHNATKRDSASGENIDVVVITKEAFKRLDPEEVKSRRALLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009512
EMBL· GenBank· DDBJ
AKB63816.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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