A0A0E3LMU2 · A0A0E3LMU2_METBA

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

Type
IDPosition(s)Description
Site93Transition state stabilizer
Active site97Proton acceptor
Binding site261Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • ORF names
      MSBRM_0618

Organism names

  • Taxonomic identifier
  • Strain
    • MS
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina

Accessions

  • Primary accession
    A0A0E3LMU2

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link220↔246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-21Basic and acidic residues
Region1-25Disordered
Domain130-420Plant heme peroxidase family profile
Region266-286Disordered
Region346-370Disordered

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    732
  • Mass (Da)
    80,928
  • Last updated
    2015-06-24 v1
  • Checksum
    396664B5742DF432
MTDERKNPETGREDKQETGRGISNRDWWPNQLKIEILHQHSSKSNPMGEDFNYAKEFKSLDLAAVKKDLAALMTDSQDWWPADFGHYGPLFIRMAWHSAGTYRAFDGRGGGGRGQQRFAPLNSWPDNVNLDKARRLLWPIKQKYGRKISWADLMILAGNVAMETMGFKTFGFGGGREDVWEPDQDVYWGPEDTWLGGDKRYSGDRNLENPLAAVQMGLIYVNPEGPNGNPDPIAAAKDIRDIFARMSMNDEETVALIAGGHAFGKTHGAGPASHVGPEPEAASIEEQGLGWKSSFGTDKGGDTITGGLEVTWTNTPTKWSNNFFRILFGYEWELTKSPAGAYQWQPKGGAGAGTIPDAHDPSKRHPPSMMTTDLSLRFDPVYEKISRHFYKNPDQLADAFARAWFKLTHRDMGPRARYLGPEVPAEELIWQDPIPAVNHKLIDEQDIASLKDKILDSGLSISQLVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPAELAKVLNTLEGIQSEFNSAASGGKKVSFADLIVLAGCAGVEQAAKNAGHDVTVPFSPGRMDALQEQTDVVSFALLEPIADGFRNYLKNQYTVSAEALLVDKAQLLTLTAPEMTVLIGGMRVLNTNFGQTQHGVFTQKPEALTNDFFVNLLDMGTEWKAVSNARDMFEGRDRKTGKVKWTGTRVDLIFGSNSQLRALAEVYGSADAQKKFIQDFVAAWTKVMNLDRFDLA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009528
EMBL· GenBank· DDBJ
AKB53616.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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