A0A0E3LMR5 · A0A0E3LMR5_METBA

Function

function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site138Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiongalactokinase activity
Molecular Functionmagnesium ion binding
Molecular Functionmevalonate kinase activity
Biological Processgalactose metabolic process
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mevalonate kinase
  • EC number
  • Short names
    MK
    ; MVK

Gene names

    • Name
      mvk
    • ORF names
      MSBRM_0483

Organism names

  • Taxonomic identifier
  • Strain
    • MS
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina

Accessions

  • Primary accession
    A0A0E3LMR5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-146GHMP kinase N-terminal
Domain209-281GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    31,623
  • Last updated
    2015-06-24 v1
  • Checksum
    F003B231890A3A6E
MISCSAPGKIYLFGEHAVVYGETAIGCAIELRTRVRVELCDSIIIQSEIGRTGIDFEKHPYISAAIEKMRELVPIDGVHLKVDSEIPVGSGLSSSAAVTIASIGALNKMFGCGLSLEEIAKMGHEIEIQVQGAASPTDTYVSTFGGVVTIPDRRKLKTPDCGIVIGDTGVFASTKELVTNVRKLRESYPHLIEPLMVVIGRISKTAEPFFQAGDYSSIGKLMNVNQGILDALGVNTFELSKLIYSSRGAGAFGAKSTGGGGGGCMVALTAPDKCTQVAEAITGAGGKAIITKPTEQGLRLE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009528
EMBL· GenBank· DDBJ
AKB53481.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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