A0A0E3LIS6 · A0A0E3LIS6_9EURY

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

122120406080100120140160180200220
Type
IDPosition(s)Description
Binding site12substrate
Binding site34substrate
Active site60For OMPdecase activity
Binding site60-69substrate
Active site62For OMPdecase activity
Active site62Proton donor
Active site65For OMPdecase activity
Binding site117substrate
Binding site170-180substrate
Binding site193substrate
Binding site194substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )

Gene names

    • Name
      pyrF
    • ORF names
      MSKOL_0759

Organism names

  • Taxonomic identifier
  • Strain
    • Kolksee
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina

Accessions

  • Primary accession
    A0A0E3LIS6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-209Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    221
  • Mass (Da)
    23,485
  • Last updated
    2015-06-24 v1
  • Checksum
    5CDAB6D550585A82
MEKKSCMILALDVSDREEALKIAEDVSEFVDAIKVGYPLILATGLGIIRELAEFAPIIADFKVADIPNTNRLICEQVFEAGAEAVIAQGFTGRDSLDACIEVASEYRKDVFVVSEMSHPGGAEFLQPVGEAITRMAAEAGAFGLVAPATRPERVKAIRKIIGEKLTIISPGVGAQGGKASDVIAAGADWVIVGRAIYKAESPREAARKIATEIEAELKGEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009524
EMBL· GenBank· DDBJ
AKB46536.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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