A0A0E3LIS6 · A0A0E3LIS6_9EURY
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids221 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- orotidine 5'-phosphate + H+ = UMP + CO2
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12 | substrate | |||
Binding site | 34 | substrate | |||
Active site | 60 | For OMPdecase activity | |||
Binding site | 60-69 | substrate | |||
Active site | 62 | For OMPdecase activity | |||
Active site | 62 | Proton donor | |||
Active site | 65 | For OMPdecase activity | |||
Binding site | 117 | substrate | |||
Binding site | 170-180 | substrate | |||
Binding site | 193 | substrate | |||
Binding site | 194 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina
Accessions
- Primary accessionA0A0E3LIS6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-209 | Orotidine 5'-phosphate decarboxylase | |||
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length221
- Mass (Da)23,485
- Last updated2015-06-24 v1
- Checksum5CDAB6D550585A82
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP009524 EMBL· GenBank· DDBJ | AKB46536.1 EMBL· GenBank· DDBJ | Genomic DNA |