A0A0E3LIN0 · A0A0E3LIN0_9EURY
- ProteinProbable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
- GenepyrK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD+.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD per subunit.
Note: Binds 1 [2Fe-2S] cluster per subunit.
Note: Binds 1 [2Fe-2S] cluster per subunit.
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 211 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 216 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 219 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
Binding site | 229 | [2Fe-2S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina
Accessions
- Primary accessionA0A0E3LIN0
Proteomes
Interaction
Subunit
Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Structure
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)28,025
- Last updated2015-06-24 v1
- ChecksumE5912688DBEF8F12
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP009524 EMBL· GenBank· DDBJ | AKB46306.1 EMBL· GenBank· DDBJ | Genomic DNA |