A0A0E3L7H3 · A0A0E3L7H3_9EURY

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site15-17shikimate (UniProtKB | ChEBI)
Binding site62shikimate (UniProtKB | ChEBI)
Active site66Proton acceptor
Binding site88shikimate (UniProtKB | ChEBI)
Binding site104shikimate (UniProtKB | ChEBI)
Binding site128-132NADP+ (UniProtKB | ChEBI)
Binding site151-156NADP+ (UniProtKB | ChEBI)
Binding site222NADP+ (UniProtKB | ChEBI)
Binding site224shikimate (UniProtKB | ChEBI)
Binding site245NADP+ (UniProtKB | ChEBI)
Binding site252shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      MSSIT_0052

Organism names

  • Taxonomic identifier
  • Strain
    • T4/M
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanosarcina

Accessions

  • Primary accession
    A0A0E3L7H3

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-90Shikimate dehydrogenase substrate binding N-terminal
Domain118-222Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain245-275SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    280
  • Mass (Da)
    29,210
  • Last updated
    2015-06-24 v1
  • Checksum
    70235BB8BBCBEDA4
MKRVFGVFGDPIGHSLSPAMHNAAFSALGMDCIYHAFRVRPENLGKAILGAGAMGFGGLNLTVPLKEEALKLDFIKPDPLAEKIGAINTVVFSETGEIRGYNTDGLGAIQALLDAAVEIEGSKVVVTGAGGAARAVTFQLAAAGAEITVVNRTAERAVELAKDVAAVALPGKISGVGLSGLKELLRDADILINTTTLGMHPNTDTTIATAEELHSELTVFDIVYNPLETRLLKEAKAAGAKTVSGVLMLVYQGAEAFKLWTGAEAPAELMKETVLEALQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009506
EMBL· GenBank· DDBJ
AKB26771.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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