A0A0E3JVA9 · A0A0E3JVA9_ANEPI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1
    • ORF names
      PlpuMp57

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A0E3JVA9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane53-79Helical
Transmembrane100-124Helical
Transmembrane144-167Helical
Transmembrane179-206Helical
Transmembrane239-255Helical
Transmembrane262-284Helical
Transmembrane296-313Helical
Transmembrane333-352Helical
Transmembrane372-392Helical
Transmembrane443-467Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    55,906
  • Last updated
    2015-06-24 v1
  • Checksum
    9AF57C8027FF6D4F
MFSTNHKDIGTLYLIFGAIAGVMGTCFSVLIRMELAQPGNQILGGNHQLYNVLITAHAFLMIFFMVMPAMIGGFGNWFVPILIGSPDMAFPRLNNISFRLLPPSLLLLLSSALVEVGCGSGWTVYPPLSGITSHSGGSVDLAIFSPHLSGVSSILGSINFITTIFNMRGPGSTMHRLPLFVWSVPVTAFPLLLSLPVLAGAITMLLTDRNFNTTFSDPAGGGDPILYQHLFRFFGHPEVYIPILPGFGIISHIVSTFSRKPVFGYLGMVYAMISIGVLGFIAWAHHMFTVGLDVDTRAYFTAATMIIAVPTGIKISSRIATMWGGSIRYKTPMLFAVGFISLFTVGGLTGIVSANSGLDIALHDTYYVVAHFHYVLSMGAVFASFAGFYYWIGKITGLQYPETLGQIHFRITFFGVNPTPFPMHFPGLAGMPRRIPDYPDAYAGWNAFSSFGSYVSVVGIFCFFVVVSPTPTSENKCASSPWAVEQNSTTPEWMVPSPPAFHTFEELPAIRESI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP728938
EMBL· GenBank· DDBJ
AKA63291.1
EMBL· GenBank· DDBJ
Genomic DNA
KR817582
EMBL· GenBank· DDBJ
AKU36867.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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