A0A0E3JUD7 · A0A0E3JUD7_SACSO

Function

function

Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site122-oxoglutarate (UniProtKB | ChEBI)
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site762-oxoglutarate (UniProtKB | ChEBI)
Binding site1362-oxoglutarate (UniProtKB | ChEBI)
Binding site1702-oxoglutarate (UniProtKB | ChEBI)
Binding site198Mg2+ (UniProtKB | ChEBI)
Binding site200Mg2+ (UniProtKB | ChEBI)
Active site292Proton acceptor

GO annotations

AspectTerm
Molecular Function2-isopropylmalate synthase activity
Molecular Functionhomocitrate synthase activity
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process
Biological Processlysine biosynthetic process via aminoadipic acid

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homocitrate synthase
  • EC number
  • Short names
    HCS

Gene names

    • Name
      lysS
    • ORF names
      SSOP1_1011
      , SULA_1989
      , SULB_1990
      , SULC_1988
      , SULG_10005
      , SULH_10005
      , SULI_10005
      , SULM_09995
      , SULN_09995
      , SULO_10005
      , SULZ_09940

Organism names

Accessions

  • Primary accession
    A0A0E3JUD7

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-259Pyruvate carboxyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    461
  • Mass (Da)
    50,882
  • Last updated
    2015-06-24 v1
  • Checksum
    E87E9E4CA21BA56F
MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDIHLKAKHKATREEALRVIAETISYARSHGVKVRFTAEDGSRTDFDFLVTVSRTARDAGADRVSIADTVGILYPSKTKELFSALIREVPNLEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGIVPLQQIVAAIKYHFGIEVVKLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLSDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAKIKSNTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVINGVKEVMEISGDYDILVKVQAKDSNELNQIIESIRATKGVRSTLTSLVLKKM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011055
EMBL· GenBank· DDBJ
AKA74204.1
EMBL· GenBank· DDBJ
Genomic DNA
CP011056
EMBL· GenBank· DDBJ
AKA76902.1
EMBL· GenBank· DDBJ
Genomic DNA
CP011057
EMBL· GenBank· DDBJ
AKA79594.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033235
EMBL· GenBank· DDBJ
AZF68684.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033236
EMBL· GenBank· DDBJ
AZF71304.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033237
EMBL· GenBank· DDBJ
AZF73924.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033238
EMBL· GenBank· DDBJ
AZF76547.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033239
EMBL· GenBank· DDBJ
AZF79155.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033240
EMBL· GenBank· DDBJ
AZF81760.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033241
EMBL· GenBank· DDBJ
AZF84335.1
EMBL· GenBank· DDBJ
Genomic DNA
LT549890
EMBL· GenBank· DDBJ
SAI84565.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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