A0A0E3GUW0 · A0A0E3GUW0_SACSO

Function

function

Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N6-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate lyase
  • EC number
  • Short names
    ASL
  • Alternative names
    • Adenylosuccinase

Gene names

    • ORF names
      HFC64_12695
      , SSOP1_0225
      , SULA_1257
      , SULB_1258
      , SULC_1256
      , SULG_06220
      , SULH_06220
      , SULI_06220
      , SULM_06220
      , SULN_06220
      , SULO_06230
      , SULZ_06465

Organism names

Accessions

  • Primary accession
    A0A0E3GUW0

Proteomes

Family & Domains

Features

Showing features for coiled coil, domain.

TypeIDPosition(s)Description
Coiled coil351-378
Domain376-456Adenylosuccinate lyase C-terminal

Sequence similarities

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    53,848
  • Last updated
    2015-06-24 v1
  • Checksum
    0BF91C5516ADCA30
MRLQYKLINVEHTLQLAMEDSICPLEWRYGSNEMRKFFSREEILKRRIQVEIALLKALTKYGLVKEEDVQKVEKASLTIRPEEVDELESKIGHDVMAMVVLMAERSGDSGRYVHFGATSYDIVDTAYALVFRDAIRLVKTKVVEILEMMVSLAIKYKDLAMVGRTHGQHALPITLGFKIANYIYEFSRSLERLNEVEKRIVKGKMAGAVGTMAAWGNIGLEIEENVMKFLGLRPHEISTQVAPRDAFAELTSDLAILASQCDRFALEVRELMRPEINEISEGVEGRVGSSTMPQKENPVTSEKIGGLAKVLRSLVVASLENIPLWHERDLTNSSSERIIISHEFLVIDEILDSMISLLRNLRVNFENIEKNLNLTKGQIMAESLMINLTLKGMKRHEAHQYVNKLTSKVRQTGKTLLEVCLEDSLILSYFSKQELENVLNPKNYLGSYDKLIERAISYAKGVIKGSEIREAQDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011055
EMBL· GenBank· DDBJ
AKA73558.1
EMBL· GenBank· DDBJ
Genomic DNA
CP011056
EMBL· GenBank· DDBJ
AKA76256.1
EMBL· GenBank· DDBJ
Genomic DNA
CP011057
EMBL· GenBank· DDBJ
AKA78948.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033235
EMBL· GenBank· DDBJ
AZF68026.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033236
EMBL· GenBank· DDBJ
AZF70646.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033237
EMBL· GenBank· DDBJ
AZF73266.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033238
EMBL· GenBank· DDBJ
AZF75891.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033239
EMBL· GenBank· DDBJ
AZF78500.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033240
EMBL· GenBank· DDBJ
AZF81104.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033241
EMBL· GenBank· DDBJ
AZF83743.1
EMBL· GenBank· DDBJ
Genomic DNA
CP050869
EMBL· GenBank· DDBJ
QPG50547.1
EMBL· GenBank· DDBJ
Genomic DNA
LT549890
EMBL· GenBank· DDBJ
SAI83779.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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