A0A0E2ZKY6 · A0A0E2ZKY6_9GAMM
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids255 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + methanol + H+
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 20 | substrate | ||||
Sequence: W | ||||||
Active site | 81 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 81-82 | substrate | ||||
Sequence: SL | ||||||
Binding site | 143-147 | substrate | ||||
Sequence: FVWLQ | ||||||
Active site | 207 | |||||
Sequence: D | ||||||
Active site | 235 | |||||
Sequence: H | ||||||
Binding site | 235 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pimelyl-[acyl-carrier protein] methyl ester esterase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Chromatiales > Chromatiaceae > Nitrosococcus
Accessions
- Primary accessionA0A0E2ZKY6
Proteomes
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-241 | AB hydrolase-1 | ||||
Sequence: LVLLHGWGFHSGVWAPLVDCLSTRFRLTLVDLPGHGGSDPLAQGRRLAAVAETVARVAPPQACWLGWSLGGLVALQAAIDFPRRVNKLVLVASTPRFVTAVDWPYGVAPEVLADFSVALQNDSVETLKRFVWLQTRGAERAKAVAQVLLAHFNAPYRPGIEGLEDGLALLQDSDLRVELETIPCPTLAIMGQRDPLVPPKVGAWLSAHLPQGQVFMIPRAGHAPFLSH |
Sequence similarities
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length255
- Mass (Da)27,577
- Last updated2015-05-27 v1
- ChecksumA4225A8CCB593875