A0A0E2HCS5 · A0A0E2HCS5_9FIRM
- ProteinPenicillin-binding protein 1A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids897 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Catalytic activity
- [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+
[GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate RHEA-COMP:9602 + CHEBI:60033 = [GlcNAc-(1→4)-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate RHEA-COMP:9603 + CHEBI:58405 + CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | penicillin binding | |
Molecular Function | peptidoglycan glycosyltransferase activity | |
Molecular Function | serine-type D-Ala-D-Ala carboxypeptidase activity | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | proteolysis | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePenicillin-binding protein 1A
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Enterocloster
Accessions
- Primary accessionA0A0E2HCS5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 26-53 | Helical | ||||
Sequence: LLLNIFKALFVLFLFLAVVGASIGFGMV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 86-269 | Glycosyl transferase family 51 | ||||
Sequence: DTLVTSGSNREEATYEELPKDLVNAFVAIEDSRFWTHNGIDIRSIARAVKGIVSDDYAGGGSTITQQLIKNNVFSGGMESGWGARIERKLQEQYLAVQLEKNSGMSKEDTKKLIITNYLNTINLGNNTLGVKVAAKRYFNKDVSDLTLSECTVLASITKNPSRLNPISGRENNAERRRIVLQYM | ||||||
Domain | 448-708 | Penicillin-binding protein transpeptidase | ||||
Sequence: SFVLLDQHTGEVKALCGGRGEKTASLTLNRASNVYRQPGSAFKVITAFAPALDACGATLGTVYYDAPYTIGNKTFRNWWNSGYGFTGYSSIRDGIIYSMNIVAVRCLMETVTPQLGVEYAENMGITSLTKDDLGAATALGGITKGVSNLELTTAYAAIANGGVYTKPRFFTKILDHNGKVLIDNEPETKQVLKDSTAFLLTDAMSESMKSNRKFTRPGVSINSTSTRAALTGMTAAGKSGTTTSNNDVWFVGYTPYYTAGI | ||||||
Compositional bias | 859-889 | Polar residues | ||||
Sequence: IPPNTNEPGNTGPTVTPIGPGYQTSPETTEG | ||||||
Region | 859-897 | Disordered | ||||
Sequence: IPPNTNEPGNTGPTVTPIGPGYQTSPETTEGFGPGNRPY |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length897
- Mass (Da)98,132
- Last updated2015-05-27 v1
- Checksum67DB3275F2E7EB73
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 859-889 | Polar residues | ||||
Sequence: IPPNTNEPGNTGPTVTPIGPGYQTSPETTEG |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGYR01000014 EMBL· GenBank· DDBJ | ENZ17454.1 EMBL· GenBank· DDBJ | Genomic DNA |