A0A0E2H7B6 · A0A0E2H7B6_9FIRM
- ProteinATP-dependent zinc metalloprotease FtsH
- GeneftsH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids604 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent zinc metalloprotease FtsH
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Enterocloster
Accessions
- Primary accessionA0A0E2H7B6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-28 | Helical | ||||
Sequence: FRGFIFILLMLILIATAVRFPY | ||||||
Transmembrane | 106-128 | Helical | ||||
Sequence: YLVTIILPFMLSIVVVVIIIMVM |
Keywords
- Cellular component
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 192-331 | AAA+ ATPase | ||||
Sequence: IPKGLLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEEAKKNSPCIVFIDEIDAVARRRGTGMGGGHDEREQTLNQLLVEMDGFGVNEGIIVMAATNRVDILDPAILRPGRFDRKVAVGRPD |
Sequence similarities
Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)66,604
- Last updated2015-05-27 v1
- ChecksumD07C4104876D71AE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGYR01000040 EMBL· GenBank· DDBJ | ENZ12169.1 EMBL· GenBank· DDBJ | Genomic DNA |