A0A0E2H7B6 · A0A0E2H7B6_9FIRM

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

160450100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site200-207ATP (UniProtKB | ChEBI)
Binding site422Zn2+ (UniProtKB | ChEBI); catalytic
Active site423
Binding site426Zn2+ (UniProtKB | ChEBI); catalytic
Binding site499Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      HMPREF1090_03800

Organism names

Accessions

  • Primary accession
    A0A0E2H7B6

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-28Helical
Transmembrane106-128Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain192-331AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    604
  • Mass (Da)
    66,604
  • Last updated
    2015-05-27 v1
  • Checksum
    D07C4104876D71AE
MRQQQTFRGFIFILLMLILIATAVRFPYARQADKVTNQDFIKILEDGQAADVNIHQNPQTPTGEVVLTLLDGQVKRLYVSDVKDAQRLLDAHDMAYTTMDVPQENYLVTIILPFMLSIVVVVIIIMVMNRSAGGGGANARMMNFGKSRARMSRDSKVNFSNVAGLVEEKEELEEVVDFLKNPQKYTSVGARIPKGLLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEEAKKNSPCIVFIDEIDAVARRRGTGMGGGHDEREQTLNQLLVEMDGFGVNEGIIVMAATNRVDILDPAILRPGRFDRKVAVGRPDVKGREEILKVHSKEKPLSEDVDLHRVAQTTSGFTGADLENLMNEAAIISARDNRRFIKQSDIDRAFVKVGIGAEKKSKVISEKDKKITAYHEAGHAILFHVLPDVGPVHTVSIIPTGIGAAGYTMPLPEKDEMFNTKGRMMQNIMVDLGGRIAEELIFDDITTGASQDIKQATQIARAMVTQYGMSEKVGMIQYGGDENEVFIGRDLAHTKSYGNEVADTIDSEVKRIIDECYQKAKDIIKQYDYVLHACAALLIEKEKISQSEFETLFTPAQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGYR01000040
EMBL· GenBank· DDBJ
ENZ12169.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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