A0A0E2H3P9 · A0A0E2H3P9_9FIRM
- ProteinPutative K(+)-stimulated pyrophosphate-energized sodium pump
- GenehppA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids660 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na+ movement across the membrane.
Catalytic activity
- Na+(in) + diphosphate + H2O = Na+(out) + 2 phosphate + H+Na+ (in)CHEBI:29101
+ CHEBI:33019 + CHEBI:15377 = Na+ (out)CHEBI:29101+ 2 CHEBI:43474 + CHEBI:15378
Cofactor
Activity regulation
Requires K+ for maximal activity.
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 441 | Determinant of potassium dependence | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | potassium ion binding | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative K(+)-stimulated pyrophosphate-energized sodium pump
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Enterocloster
Accessions
- Primary accessionA0A0E2H3P9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endomembrane system ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-26 | Helical | |||
Transmembrane | 47-70 | Helical | |||
Transmembrane | 76-101 | Helical | |||
Transmembrane | 122-148 | Helical | |||
Transmembrane | 154-171 | Helical | |||
Transmembrane | 224-242 | Helical | |||
Transmembrane | 248-271 | Helical | |||
Transmembrane | 283-303 | Helical | |||
Transmembrane | 309-330 | Helical | |||
Transmembrane | 351-376 | Helical | |||
Transmembrane | 382-403 | Helical | |||
Transmembrane | 442-463 | Helical | |||
Transmembrane | 475-498 | Helical | |||
Transmembrane | 546-564 | Helical | |||
Transmembrane | 570-589 | Helical | |||
Transmembrane | 637-654 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length660
- Mass (Da)68,042
- Last updated2015-05-27 v1
- ChecksumBAD901CE7B5574A3
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGYR01000058 EMBL· GenBank· DDBJ | ENZ08883.1 EMBL· GenBank· DDBJ | Genomic DNA |