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A0A0E1RWZ7 · A0A0E1RWZ7_COCIM

Function

function

Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence.

Catalytic activity

  • Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.
    EC:3.4.24.39 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

135750100150200250300350
Type
IDPosition(s)Description
Binding site308Zn2+ (UniProtKB | ChEBI); catalytic
Active site309
Binding site312Zn2+ (UniProtKB | ChEBI); catalytic
Binding site323Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Neutral protease 2
  • EC number
  • Alternative names
    • Deuterolysin

Gene names

    • ORF names
      CIMG_08613

Organism names

Accessions

  • Primary accession
    A0A0E1RWZ7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500511657222-357Neutral protease 2
Disulfide bond187↔259
Disulfide bond266↔284

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase M35 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    39,041
  • Last updated
    2015-05-27 v1
  • MD5 Checksum
    81ABB6B4BAE9B622AA72BD5071A2F44E
MLLCSMVAALAALATPAFSCALPHLDLPEDNSGLDIKLDSLSNTRVKATITNKADRPLNLLKFNTFFDDGPTEKVGIFKDGNPIKFDGIMRRIQTFDLPISAFVPISPGESIEREFDIASTSDLTVGGAFDILSEGAIPYAEANQTTLTGAMVFKSNALQLKIDGEMAATVARAIQPLDRRSDVHVCRNSAKRKALMKALRNSAHLAGTAASAAYRNPRKVQEYFHTTDRTAVRSVAARLKAISRESGSTRNGATRYACEDHWNRCEPGVLAYTLPSHNLVVNCPSFYNLPALTNRCHGQDQATTVLHEFAHAPGVHEPFCKDHAYGYRSIRRLSTRLALNNADSFSLFANAINLRC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG704913
EMBL· GenBank· DDBJ
EAS29867.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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