A0A0E1CLX1 · A0A0E1CLX1_KLEPN

Function

function

Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site171Mg2+ (UniProtKB | ChEBI)
Binding site235Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGram-negative-bacterium-type cell wall
Cellular Componentplasma membrane
Molecular Functionglycosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular FunctionUDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processcell wall macromolecule biosynthetic process
Biological Processcell wall organization
Biological Processenterobacterial common antigen biosynthetic process
Biological ProcessO antigen biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
  • EC number
  • Alternative names
    • UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase
    • Undecaprenyl-phosphate GlcNAc-1-phosphate transferase

Gene names

    • Name
      wecA
    • ORF names
      KPNJ1_05309

Organism names

  • Taxonomic identifier
  • Strain
    • 30660/NJST258_1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0E1CLX1

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-42Helical
Transmembrane63-84Helical
Transmembrane90-107Helical
Transmembrane119-144Helical
Transmembrane150-167Helical
Transmembrane179-197Helical
Transmembrane203-220Helical
Transmembrane232-250Helical
Transmembrane262-281Helical
Transmembrane312-333Helical
Transmembrane339-360Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. WecA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    385
  • Mass (Da)
    42,905
  • Last updated
    2015-05-27 v1
  • Checksum
    C4425145F7146503
MGHHRYTSRINYAESTCVVNLLTAITELISIFLFTTLFIFVARKVAKKIGLVDKPNYRKRHQGLIPLVGGISVYAGICFTFAIADYYIPHASLYLACAGVLVLVGALDDRFDISVKIRAVIQAAIAVIMMMAGNLHLSSLGFIFGSWELVLGPFGFFLTLFAVWAAINAFNMVDGIDGLLGGLSSVSFAATGIILWFDGQYSLAMWCFAMIAAILPYILLNLGALGRRYKVFMGDAGSTMIGFTIIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLALVGVVAEYTRIVPEWVMLILFLVAFFLYGYCIKRAWKVARLVKRIRRRIRRHSGNNPKLTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP006923
EMBL· GenBank· DDBJ
AHM87701.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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