A0A0E1CLX1 · A0A0E1CLX1_KLEPN
- ProteinUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- GenewecA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids385 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
Catalytic activity
- di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
Cofactor
Protein has several cofactor binding sites:
Pathway
Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Gram-negative-bacterium-type cell wall | |
Cellular Component | plasma membrane | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity | |
Biological Process | cell wall macromolecule biosynthetic process | |
Biological Process | cell wall organization | |
Biological Process | enterobacterial common antigen biosynthetic process | |
Biological Process | O antigen biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A0E1CLX1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-42 | Helical | ||||
Sequence: NLLTAITELISIFLFTTLFIFVA | ||||||
Transmembrane | 63-84 | Helical | ||||
Sequence: GLIPLVGGISVYAGICFTFAIA | ||||||
Transmembrane | 90-107 | Helical | ||||
Sequence: HASLYLACAGVLVLVGAL | ||||||
Transmembrane | 119-144 | Helical | ||||
Sequence: AVIQAAIAVIMMMAGNLHLSSLGFIF | ||||||
Transmembrane | 150-167 | Helical | ||||
Sequence: VLGPFGFFLTLFAVWAAI | ||||||
Transmembrane | 179-197 | Helical | ||||
Sequence: LLGGLSSVSFAATGIILWF | ||||||
Transmembrane | 203-220 | Helical | ||||
Sequence: LAMWCFAMIAAILPYILL | ||||||
Transmembrane | 232-250 | Helical | ||||
Sequence: FMGDAGSTMIGFTIIWILL | ||||||
Transmembrane | 262-281 | Helical | ||||
Sequence: PVTALWIIAIPLMDMVAIMY | ||||||
Transmembrane | 312-333 | Helical | ||||
Sequence: AFVLITLAAALLALVGVVAEYT | ||||||
Transmembrane | 339-360 | Helical | ||||
Sequence: WVMLILFLVAFFLYGYCIKRAW |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the glycosyltransferase 4 family. WecA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)42,905
- Last updated2015-05-27 v1
- ChecksumC4425145F7146503
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP006923 EMBL· GenBank· DDBJ | AHM87701.1 EMBL· GenBank· DDBJ | Genomic DNA |