A0A0E0REK3 · A0A0E0REK3_ORYRU
- ProteinNAD-dependent protein deacylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids454 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Catalytic activity
- H2O + N6-acetyl-L-lysyl-[protein] + NAD+ = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 259-262 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: QNVD | ||||||
Active site | 276 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 284 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 287 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 351 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 354 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 435 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrial matrix | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent protein lysine deacetylase activity | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD-dependent protein deacylase
- EC number
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza
Accessions
- Primary accessionA0A0E0REK3
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-34 | Helical | ||||
Sequence: GLGPVGLIVLGLVFPLHVALVYF |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 43-82 | Disordered | ||||
Sequence: PSSFAARHHVGRPPPPPPPEREGLPDPPRQEGSNGGGGAR | ||||||
Domain | 152-454 | Deacetylase sirtuin-type | ||||
Sequence: PDSDPPSAKDVDLLYRFIDQSKKLMVLTGAGMSTESGIPDYRSPNGAYSSGFKPLTHQEFVRSIRARRRYWARSYAGWRRFRRAQPNSAHYALASLERIGRVHSMVTQNVDRLHHRAGSKPVELHGSVYEVACLDCGTSIDRESFQEQVKDLNPKWALAIDSLEVGQPGSDKSFGMQQRPDGDIEIDEKFWEQDFDIPSCNQCGGVLKPDVVMFGDNVPEERAESTKEAARNCDALLVVGSALMTMSAFRLARLAHEANAPIAAITIGETRADSILSLKINARCGEILPRILQMGSLSVPNVS |
Sequence similarities
Belongs to the sirtuin family. Class II subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length454
- Mass (Da)50,291
- Last updated2015-05-27 v1
- ChecksumAD393D23A3955E4E
Keywords
- Technical term