A0A0E0REK3 · A0A0E0REK3_ORYRU

Function

function

NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site259-262NAD+ (UniProtKB | ChEBI)
Active site276Proton acceptor
Binding site284Zn2+ (UniProtKB | ChEBI)
Binding site287Zn2+ (UniProtKB | ChEBI)
Binding site351Zn2+ (UniProtKB | ChEBI)
Binding site354Zn2+ (UniProtKB | ChEBI)
Binding site435NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrial matrix
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent protein lysine deacetylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog

Organism names

  • Taxonomic identifier
  • Strain
    • cv. W1943
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza

Accessions

  • Primary accession
    A0A0E0REK3

Proteomes

Genome annotation databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region43-82Disordered
Domain152-454Deacetylase sirtuin-type

Sequence similarities

Belongs to the sirtuin family. Class II subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    50,291
  • Last updated
    2015-05-27 v1
  • Checksum
    AD393D23A3955E4E
MYIYIRLTTWAGLGPVGLIVLGLVFPLHVALVYFPPNKKTKSPSSFAARHHVGRPPPPPPPEREGLPDPPRQEGSNGGGGARVARFGSGFSPQLCNFHASVNNGLLHRRKIQLHFICSFRSIQARYNHSSAVAPKDYCETYIQFLRDKQIVPDSDPPSAKDVDLLYRFIDQSKKLMVLTGAGMSTESGIPDYRSPNGAYSSGFKPLTHQEFVRSIRARRRYWARSYAGWRRFRRAQPNSAHYALASLERIGRVHSMVTQNVDRLHHRAGSKPVELHGSVYEVACLDCGTSIDRESFQEQVKDLNPKWALAIDSLEVGQPGSDKSFGMQQRPDGDIEIDEKFWEQDFDIPSCNQCGGVLKPDVVMFGDNVPEERAESTKEAARNCDALLVVGSALMTMSAFRLARLAHEANAPIAAITIGETRADSILSLKINARCGEILPRILQMGSLSVPNVS

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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