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A0A0E0FBG3 · A0A0E0FBG3_9ORYZ

  • Protein
    Telomerase reverse transcriptase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componenttelomerase catalytic core complex
Molecular Functionmetal ion binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular Functiontelomerase RNA binding
Molecular Functiontelomeric DNA binding
Biological Processtelomere maintenance via telomerase

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Telomerase reverse transcriptase
  • EC number
  • Alternative names
    • Telomerase catalytic subunit

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • OR44
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza

Accessions

  • Primary accession
    A0A0E0FBG3

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-116Disordered
Compositional bias70-87Polar residues
Domain666-949Reverse transcriptase

Sequence similarities

Belongs to the reverse transcriptase family. Telomerase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,141
  • Mass (Da)
    129,285
  • Last updated
    2015-05-27 v1
  • MD5 Checksum
    2AAD62C68CD97068BCEE464D662F162A
MEVEEAESHGRAVRRAAPTPPRRQARVLGLLAPALSRAPVRPGLCRPSVQGSAGRLSGGPPACQPSVQGQRRRPPIQGTTTSPSTVHPGHPDDDAPLQNPASNGQKPPIPLSPTGPLRCRLVLHPPHFPVAMPRRRRRRAAPGGQVPPELRLAYGARALTLGRAVFSLLPSPRHRESPCPACRGRVASGCLACRRWEHLLRDGDPVAYRRLITRAVCAIAADDLSAPPPPRYTPGNSGHSQARLVREMMKSIVADQSHGTKNVLCNGLHEGGQSICISDLVSSSSWSILLHRIGDLLMCYLLRSLVFHSMWFCEILYLQVLLRENINPKLQKQNVIHTCKIVTQQSCETCGSIRRAESKDPSEGCNCPKFPSDGRSEECCNCYTHNTRKRKRLYSWQRRSKKKQVCSVDESSAEWSKLNGSNFNMSNGPSENLAGKMNDQAQSVELTVDNNSLARSNDDSSSEIEVINATILSSEKSPCSVFDIRGSQGLSCHYSLSEVQYQSTCPQVGPSSYLHLNSCSICFNCIISNASKHLSLDSLISRNEGQPIVSSIANVAPDVTKNDGKAHYPPGGKAAYYDRSFSRLEAYSTHQQVASFVWAVLKRIVPKPLLGNSFGKRSLRTNIWKFIKLQRESKRYDVFYYPKSVWRDLTSNAIASLNKKNFRILRGEPRKAVRHLNCSSRVRFLPKAKDMRPLVNLRAKSKDANLNKCHLIMKKLRDEKPEMFGSSVFDYNNVHQNLSQFISSKRSQLMKKLKVYIVVADVSKAFDCVSHDMVLKMIDDAFKCDEYTVRKCSKGTICRVLKEQFHHLLYEQIKCNILKIGQKYYLQQVGIAQGSKLSPNLCSLYYGHLENSVLSKFLHDSKLNAGEAFSEPEYLLMRFIDDFIFISFSLEHAQKFLNRMRRGFVFYNCYMNDSKYGFNFCAGNSEPSSNRLYRGDDGVSFMPWSGLLINCETLEIQADYTRYLDITIISTITVKMHSSTKYIHSKLCHYMRPKCHPIFYDSNINSPGTIRVNIYQAFLLCAMKFHCYIRSISDANVSKLELLQVIKRTFRYMHSLIVRRMQDVELHYNVRPVLKLRRKETIWLGLTAYIRVLQQKQSRYKDMLTLLTAELGRYCHLGHECDTLRYAVDDSHSSMFWKFKF

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0E0FBG4A0A0E0FBG4_9ORYZ1052
A0A0E0FBG5A0A0E0FBG5_9ORYZ992
A0A0E0FBG6A0A0E0FBG6_9ORYZ1104
A0A0E0FBG7A0A0E0FBG7_9ORYZ1041
A0A0E0FBG8A0A0E0FBG8_9ORYZ868

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-87Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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