A0A0D9RUK7 · A0A0D9RUK7_CHLSB

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Cellular Componentnuclear lamina
Molecular Functionchromatin-protein adaptor activity
Molecular Functionchromo shadow domain binding
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionDNA binding
Molecular FunctionNADPH binding
Biological Processcholesterol biosynthetic process
Biological Processneutrophil differentiation
Biological Processrandom inactivation of X chromosome

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase LBR
  • EC number
  • Short names
    C14SR
    ; Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Integral nuclear envelope inner membrane protein
    • Lamin-B receptor
    • Sterol C14-reductase

Gene names

    • Name
      LBR

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Chlorocebus

Accessions

  • Primary accession
    A0A0D9RUK7

Proteomes

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Nucleus inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane303-321Helical
Transmembrane333-353Helical
Transmembrane421-439Helical
Transmembrane459-477Helical
Transmembrane489-508Helical
Transmembrane559-583Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-62Tudor
Region52-110Disordered
Compositional bias61-75Polar residues
Compositional bias76-90Basic residues
Region127-148Disordered
Compositional bias134-148Basic and acidic residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    622
  • Mass (Da)
    71,319
  • Last updated
    2015-05-27 v1
  • Checksum
    E2B4F6B9EB382913
MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQANIKEARREVEVKLTPLILKPFGNSISRYNGEPEHTERNDVPHKNTQEKFNLSQESSYISTQYSLRPRREEVKLKEIDSKEEKFIAKELAVRTFEVTPIRAKDLEFGGVPDVSNGFKCCQMVSNVFVVKNILCCFQIPAISLKFVSPLPWWNCIIKRLATGVFEMYYKISLLQDIFLLGLVEKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGASLFQGVEFHYVYSHFLQFALGATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAIPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPSEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYVIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias61-75Polar residues
Compositional bias76-90Basic residues
Compositional bias134-148Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AQIB01130280
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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