A0A0D9R866 · A0A0D9R866_CHLSB

Function

function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentclathrin-coated pit
Cellular Componentearly endosome
Cellular Componentendosome membrane
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular exosome
Cellular ComponentHFE-transferrin receptor complex
Cellular Componentmelanosome
Cellular Componentperinuclear region of cytoplasm
Cellular Componentpostsynapse
Cellular Componentrecycling endosome
Molecular Functiondouble-stranded RNA binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein kinase binding
Molecular Functionprotein-containing complex binding
Molecular Functiontransferrin receptor activity
Biological Processcellular response to leukemia inhibitory factor
Biological Processcellular response to xenobiotic stimulus
Biological Processintracellular iron ion homeostasis
Biological Processintracellular signal transduction
Biological Processmulticellular organismal-level iron ion homeostasis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of mitochondrial fusion
Biological Processosteoclast differentiation
Biological Processpositive regulation of B cell proliferation
Biological Processpositive regulation of bone resorption
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of isotype switching
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of peptidyl-serine phosphorylation
Biological Processpositive regulation of protein localization to nucleus
Biological Processpositive regulation of protein-containing complex assembly
Biological Processpositive regulation of T cell proliferation
Biological Processreceptor internalization
Biological Processregulation of postsynaptic membrane neurotransmitter receptor levels
Biological Processtransferrin transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transferrin receptor protein 1

Gene names

    • Name
      TFRC

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Chlorocebus

Accessions

  • Primary accession
    A0A0D9R866

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane80-102Helical

Keywords

PTM/Processing

Post-translational modification

Stearoylated.

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain242-328PA
Domain402-591Peptidase M28
Domain651-763Transferrin receptor-like dimerisation

Sequence similarities

Belongs to the peptidase M28 family. M28B subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    774
  • Mass (Da)
    86,315
  • Last updated
    2015-05-27 v1
  • MD5 Checksum
    AE22EBEDC76BD3FDF7F39B96D69E1335
MLGDEQGSFVWQFGMMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLGVDEEENADNNTKANGTKPKRCGGNICYGTIAVIIFFLIGFMIGYLGYCKGVEPKTECERLAGTESPVREEPEEDFPAAPRLYWDDLKKKLSEKLDATDFTSTIKLLNENLYVPREAGSQKDENLALYIENQFREFKLSKVWRDQHFVKIQVKDSAQNSVIIVDKNGGLVYLVENPGGYVAYSKAATVTGKLVHANFGTKKDFEGLDSPVNGSVVIVRAGKITFAEKVANAESLNAIGVLIYMDRTKFPIVKADLSFFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAAAEKLFGNMEGDCPSDWKTDSTCKMVTSENKSVKLTVSNVLKETKILNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSSVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQDVKHPVTGRSLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTSMDTYKELVERIPELNKVARAAAEVAGQFVIKLTHDIELNLDYERYNSQLLLFLRDLNQYRADVKEMGLSLQWLYSARGDFFRATSRLTTDFRNAEKTDKFVMKKLNDRVMRVEYYFLSPYVSPKESPFRHVFWGSGAHTLSALLENLKLRRQNNSAFNETLFRNQLALATWTIQGAANALSGDVWDIDNEF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AQIB01076837
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AQIB01076838
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AQIB01076839
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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