A0A0D9R054 · A0A0D9R054_CHLSB
- ProteinProthrombin
- GeneF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids596 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Thrombin triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells.
Catalytic activity
Features
Showing features for site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 206-207 | Cleavage; by thrombin | |||
Site | 335-336 | Cleavage; by factor Xa | |||
Site | 371-372 | Cleavage; by factor Xa | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProthrombin
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Chlorocebus
Accessions
- Primary accessionA0A0D9R054
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5002344330 | 25-596 | Prothrombin | ||
Disulfide bond | 68↔73 | ||||
Disulfide bond | 98↔111 | ||||
Disulfide bond | 116↔194 | ||||
Glycosylation | 129 | N-linked (GlcNAc...) (complex) asparagine | |||
Disulfide bond | 137↔177 | ||||
Glycosylation | 151 | N-linked (GlcNAc...) (complex) asparagine | |||
Disulfide bond | 165↔189 | ||||
Disulfide bond | 221↔299 | ||||
Disulfide bond | 242↔282 | ||||
Disulfide bond | 270↔294 | ||||
Disulfide bond | 399↔415 | ||||
Glycosylation | 424 | N-linked (GlcNAc...) (complex) asparagine | |||
Disulfide bond | 510↔524 | ||||
Disulfide bond | 538↔568 | ||||
Keywords
- PTM
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length596
- Mass (Da)66,622
- Last updated2015-05-27 v1
- MD5 ChecksumBBC186D4313EF3C1DB04884285A807B8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AQIB01081125 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AQIB01081126 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AQIB01081127 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AQIB01081128 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AQIB01081129 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AQIB01081130 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |